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跟腱断裂术后患者报告结局的改善与手术时间的缩短有关。

Reduced Time to Surgery Improves Patient-Reported Outcome After Achilles Tendon Rupture.

机构信息

Integrative Orthopedic Laboratory, Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.

Department of Psychiatry, Tiohundra AB, Norrtälje, Sweden.

出版信息

Am J Sports Med. 2018 Oct;46(12):2929-2934. doi: 10.1177/0363546518793655. Epub 2018 Aug 31.

DOI:10.1177/0363546518793655
PMID:30169112
Abstract

BACKGROUND

Patient outcome after an acute Achilles tendon rupture (ATR) continues to be suboptimal and heterogeneous. Thus, prognostic factors are called for to optimize evidence-based ATR treatment protocols; however, the influence of delayed time from injury to surgery (TTS) on patient outcome after ATR remains largely unknown.

PURPOSE

To determine whether patient outcomes and adverse events after surgical repair of acute ATR are related to delayed TTS.

STUDY DESIGN

Cohort study; Level of evidence, 3.

METHODS

Two hundred twenty-eight patients with ATR who were treated with uniform anesthetic and surgical techniques, within 10 days after injury, were retrospectively assessed. TTS depended on availability of the operating theater, and neither surgeon nor patient could influence the TTS. Patients were assigned to 1 of 3 groups: short TTS (<48 hours), intermediate TTS (48-72 hours), and long TTS (>72 hours). Patient-reported outcome at 1 year was assessed with the validated Achilles tendon Total Rupture Score, with scores higher than 80 on a 0- to 100-point scale indicating an overall good outcome. The incidences of adverse events (perioperative and postoperative) and deep venous thrombosis were assessed.

RESULTS

Short TTS was significantly associated with increased rate of good outcome and reduced risk of adverse events. Seventy-one percent (95% CI, 60%-83%) of the patients with short TTS attained a good outcome compared with 44% (95% CI, 33%-56%) of the patients with long TTS ( P = .002), with the intermediate TTS group in between, 63% (95% CI, 47%-78%). The incidence of adverse events was significantly reduced among patients with short TTS, 1.4% (95% CI, 1%-4%) compared with those with intermediate TTS, 11% (95% CI, 2%-21%) ( P = .035) and those with long TTS, 14.8% (95% CI, 7%-23%) ( P = .003). The risk of sustaining a deep venous thrombosis was not statistically significantly different among the 3 groups ( P = .15).

CONCLUSION

Patients with acute ATR undergoing operation within 48 hours after injury had better outcomes and a lower number of adverse events compared with patients undergoing operation after 72 hours. These results align with evidence-based recommendations from other surgical disciplines and should be used as guidelines for optimizing ATR treatment protocols. Registration: NTC01317160 (ClinicalTrials.gov identifier).

摘要

背景

急性跟腱断裂(ATR)患者的预后仍然不理想且存在异质性。因此,需要预测因素来优化基于证据的 ATR 治疗方案;然而,ATR 后延迟手术时间(TTS)对患者预后的影响在很大程度上仍不清楚。

目的

确定手术修复急性 ATR 后患者的结局和不良事件是否与延迟 TTS 有关。

研究设计

队列研究;证据水平,3 级。

方法

回顾性评估了 228 例因 ATR 接受相同麻醉和手术技术治疗、伤后 10 天内的患者。TTS 取决于手术手术室的可用性,外科医生和患者均无法影响 TTS。患者被分为 3 组之一:短 TTS(<48 小时)、中 TTS(48-72 小时)和长 TTS(>72 小时)。使用经过验证的跟腱总断裂评分评估患者 1 年时的患者报告结局,评分高于 0-100 分量表上的 80 分表示总体良好结局。评估不良事件(围手术期和术后)和深静脉血栓形成的发生率。

结果

短 TTS 与更高的良好结局发生率和降低的不良事件风险显著相关。与长 TTS 组(44% [95% CI,33%-56%])相比,短 TTS 组有 71%(95% CI,60%-83%)的患者获得了良好结局,而中 TTS 组为 63%(95% CI,47%-78%)。短 TTS 组的不良事件发生率显著降低,为 1.4%(95% CI,1%-4%),而中 TTS 组为 11%(95% CI,2%-21%)(P=.035),长 TTS 组为 14.8%(95% CI,7%-23%)(P=.003)。3 组之间深静脉血栓形成的风险无统计学显著差异(P=.15)。

结论

与伤后 72 小时以上手术的患者相比,伤后 48 小时内接受手术的急性 ATR 患者的结局更好,不良事件更少。这些结果与其他外科专业的循证建议一致,应作为优化 ATR 治疗方案的指南。注册:NTC01317160(ClinicalTrials.gov 标识符)。

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