Molecular Medicine Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan, P.R. China.
West China School of Basic Medical Science and Forensic Medicine, Sichuan University, Chengdu, Sichuan, P.R. China.
Clin Chem Lab Med. 2019 Mar 26;57(4):417-441. doi: 10.1515/cclm-2018-0380.
Recently, nuclear magnetic resonance spectroscopy (NMR)-based metabolomics analysis and multivariate statistical techniques have been incorporated into a multidisciplinary approach to profile changes in small molecules associated with the onset and progression of human diseases. The purpose of these efforts is to identify unique metabolite biomarkers in a specific human disease so as to (1) accurately predict and diagnose diseases, including separating distinct disease stages; (2) provide insights into underlying pathways in the pathogenesis and progression of the malady and (3) aid in disease treatment and evaluate the efficacy of drugs. In this review we discuss recent developments in the application of NMR-based metabolomics in searching disease biomarkers in human blood samples in the last 5 years.
最近，基于核磁共振光谱（NMR）的代谢组学分析和多元统计技术已被纳入多学科方法中，以分析与人类疾病的发生和发展相关的小分子的变化。这些努力的目的是在特定的人类疾病中识别独特的代谢生物标志物，以便：（1）准确预测和诊断疾病，包括区分不同的疾病阶段；（2）深入了解疾病发病机制和进展中的潜在途径；（3）辅助疾病治疗并评估药物疗效。在这篇综述中，我们讨论了过去 5 年中基于 NMR 的代谢组学在人类血液样本中寻找疾病生物标志物方面的应用的最新进展。
