Borozdina Anastasia, Qeva Ega, Cinicola Marco, Bilotta Federico
Department of Anaesthesiology and Intensive Care, First Moscow City Hospital named after N.I. Pirogov, Moscow, Russia.
Department of Anesthesiology, Critical Care and Pain Medicine, 'Sapienza' University, Rome, Italy.
Curr Opin Anaesthesiol. 2018 Dec;31(6):756-761. doi: 10.1097/ACO.0000000000000658.
This article reviews the recent clinical evidence published between January 2017 and June 2018 - related to perioperative cognitive evaluation. Namely, new insights into risk factors, prevention, diagnosis and diagnostic tools and treatment.
Several risk factors (preoperative, intraoperative and postoperative) have been found to be associated with the development of postoperative delirium (POD) and/or postoperative cognitive dysfunction (POCD). Short-term and long-term postoperative consequences can be reduced by targeting risk factors, introducing preventive strategies and including frequent cognitive monitoring. Administration of medications such as ketamine, opioids and benzodiazepines are associated with increased cognitive dysfunction. Prevention of POD/POCD starts with creating an environment, which promotes return to preoperative baseline functioning. This includes frequent monitoring of cognitive status, access to rehabilitation and psychological and social supports, and avoiding polypharmacy. In addition, patients should have early access to their sensory aids and maintain normal circadian rhythm. Treatment of POD/POCD has pharmacological and nonpharmacological approaches.
Clinical evidence on POD/POCD is continuously evolving, which is essential in guiding clinical management to provide the highest quality of clinical care.
本文回顾了2017年1月至2018年6月期间发表的与围手术期认知评估相关的近期临床证据。具体而言,是关于危险因素、预防、诊断及诊断工具和治疗方面的新见解。
已发现若干危险因素(术前、术中和术后)与术后谵妄(POD)和/或术后认知功能障碍(POCD)的发生有关。通过针对危险因素、引入预防策略并进行频繁的认知监测,可降低术后短期和长期后果。使用氯胺酮、阿片类药物和苯二氮䓬类药物等与认知功能障碍增加有关。预防POD/POCD始于营造一个促进恢复到术前基线功能的环境。这包括频繁监测认知状态、获得康复以及心理和社会支持,避免多种药物联合使用。此外,患者应尽早使用其感官辅助器具并维持正常的昼夜节律。POD/POCD的治疗有药物和非药物方法。
关于POD/POCD的临床证据在不断发展,这对于指导临床管理以提供最高质量的临床护理至关重要。