褪黑素对老年患者术后认知功能障碍影响的研究进展
Progress in Research on the Effect of Melatonin on Postoperative Cognitive Dysfunction in Older Patients.
作者信息
Wei Yuqing, Zhang Chunlu, Wang Danyang, Wang Chengping, Sun Lin, Chen Peng
机构信息
Department of Anesthesiology, China-Japan Union Hospital, Jilin University, Changchun, China.
出版信息
Front Aging Neurosci. 2022 Mar 9;14:782358. doi: 10.3389/fnagi.2022.782358. eCollection 2022.
Abstract
Postoperative cognitive dysfunction (POCD) is a common complication of the central nervous system in elderly patients after operation. It will prolong the length of stay, reduce the independence and quality of daily life, and increase the risk of death. However, at present, there is a lack of safe and effective ideal drugs for the prevention and treatment of POCD. Melatonin is one of the hormones secreted by the pineal gland of the brain, which has the functions of regulating circadian rhythm, anti-inflammation, anti-oxidation, anti-apoptosis, and so on. Some recent studies have shown that MT can prevent and treat POCD by adjusting circadian rhythm, restoring cholinergic system function, neuroprotection, and so on. This article will introduce POCD, melatonin and the mechanism of melatonin on POCD, respectively, to provide a basis for clinical prevention and treatment of POCD in the elderly.
摘要
术后认知功能障碍（POCD）是老年患者术后常见的中枢神经系统并发症。它会延长住院时间，降低日常生活的独立性和质量，并增加死亡风险。然而，目前缺乏安全有效的理想药物用于预防和治疗POCD。褪黑素是大脑松果体分泌的激素之一，具有调节昼夜节律、抗炎、抗氧化、抗凋亡等功能。最近的一些研究表明，褪黑素可以通过调节昼夜节律、恢复胆碱能系统功能、神经保护等作用来预防和治疗POCD。本文将分别介绍POCD、褪黑素以及褪黑素对POCD的作用机制，为临床预防和治疗老年患者POCD提供依据。
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