Faulkner-Valle G P, De Rossi A, Dalla Gassa O, Chieco-Bianchi L
Tumori. 1986 Jun 30;72(3):219-24. doi: 10.1177/030089168607200301.
Serum samples which had previously been found positive for LAV/HTLV-III antibodies by the ELISA test and then confirmed by radioimmunoassay (Western blot) were tested for the presence of neutralizing antibodies. No neutralizing activity was found in the sera of a group of patients with the clinical diagnosis of AIDS. However in patients with LAS and other related pathologic conditions the percentage of sera positive for neutralizing antibodies was 27% and 55% respectively. At least 50% of the sera from seropositive asymptomatic individuals had neutralizing activity but with the exception of the haemophiliac group the mean titre was much lower than that of LAS patients. No relationship was found between the neutralizing titre and the antibody specificity detected by Western blot analysis for p41 and p120.
通过酶联免疫吸附测定（ELISA）检测先前发现LAV/HTLV-III抗体呈阳性并随后经放射免疫测定（蛋白质印迹法）确认的血清样本，以检测其中是否存在中和抗体。在一组临床诊断为艾滋病的患者血清中未发现中和活性。然而，在患有LAS和其他相关病理状况的患者中，中和抗体呈阳性的血清百分比分别为27%和55%。至少50%的血清学阳性无症状个体的血清具有中和活性，但除血友病患者组外，平均滴度远低于LAS患者。在中和滴度与通过蛋白质印迹分析检测到的针对p41和p120的抗体特异性之间未发现相关性。
