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慢性创伤性脑病:马仍在追逐马车。

Chronic Traumatic Encephalopathy: The Horse Is Still Chasing the Cart.

出版信息

J Orthop Sports Phys Ther. 2018 Sep;48(9):672-675. doi: 10.2519/jospt.2018.0612.

DOI:10.2519/jospt.2018.0612
PMID:30170520
Abstract

Chronic traumatic encephalopathy (CTE) occupies a unique and expanding position in both the scientific and lay communities concerned with sport participation at all levels. The benefits of rapid, widespread reporting and increased public awareness are counterbalanced by misinformation and an oversimplification of an increasingly complex topic. In this Viewpoint, we will describe the current understanding of CTE pathology and proposed criteria for characterizing traumatic encephalopathy syndrome (TES), the proposed clinical syndrome associated with underlying CTE pathology, but possibly other proteinopathies as well. We want to emphasize that CTE and TES are not the same entity, at least according to our current understanding. We additionally highlight those at greatest risk for CTE and the significant challenges to symptom attribution specific to these populations. J Orthop Sports Phys Ther 2018;48(9):672-675. doi:10.2519/jospt.2018.0612.

摘要

慢性创伤性脑病(CTE)在关注各级运动参与的科学界和非科学界中占据着独特且不断扩大的地位。快速广泛报道和公众意识增强的好处,与错误信息和对日益复杂主题的过度简化相平衡。在本观点中,我们将描述当前对 CTE 病理学的理解和用于描述创伤性脑病综合征(TES)的建议标准,即与潜在 CTE 病理学相关的拟议临床综合征,但也可能与其他蛋白病有关。我们想强调的是,根据我们目前的理解,CTE 和 TES 不是同一个实体。我们还强调了那些患 CTE 风险最大的人群,以及这些人群中症状归因的重大挑战。J Orthop Sports Phys Ther 2018;48(9):672-675.doi:10.2519/jospt.2018.0612.

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Brain. 2019 Dec 1;142(12):3672-3693. doi: 10.1093/brain/awz286.
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J Neuropathol Exp Neurol. 2019 Jul 1;78(7):615-625. doi: 10.1093/jnen/nlz045.