Dept. of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden; Dept. of Medicine, Health and Social Studies, Dalarna University, Falun, Sweden; Dept. of Medical Sciences: Clinical Physiology, Uppsala University, Uppsala, Sweden.
Center for Health Technology and Services Research, Faculty of Medicine of University of Porto, Porto, Portugal.
Respir Med. 2018 Sep;142:94-100. doi: 10.1016/j.rmed.2018.07.011. Epub 2018 Jul 20.
Low-grade systemic inflammation, mainly assessed by C-reactive protein (CRP), has been associated with impaired lung function. Few studies have studied if CRP, blood eosinophils, and blood neutrophils offer additive information in relation to lung function.
To analyse associations between lung function and CRP, blood eosinophils, and blood neutrophils, with special regard to additive information of combining the inflammatory markers.
Cross-sectional study on 7753 participants, 20-80 years of age, in the National Health and Nutrition Examination Survey. Gender-based tertiles for CRP, blood eosinophils, and blood neutrophils were analysed in relation to the following lung function parameters: forced expiratory volume in 1 s (FEV% predicted), forced vital capacity (FVC % predicted), and FEV/FVC ratio.
CRP, blood eosinophils, and blood neutrophils levels were inversely related to FEV and FVC. Only blood eosinophils and blood neutrophils were inversely related to FEV/FVC ratio. Further, lower lung function was found with increased number of elevated inflammatory markers in the highest tertile (one, two or three vs. non elevated) for FEV (β-coeff., -2.20, -4.43, and -6.43, p < 0.001) and FVC (β-coeff., -1.70, -3.15 and -5.33, p < 0.001), respectively.
CONCLUSIONS & CLINICAL RELEVANCE: CRP, blood eosinophils, and blood neutrophils offer independent and additive information in relation to lower FEV and FVC in the general population. This indicates that a combination of biomarkers yields more information than the biomarkers assessed individually.
低水平全身炎症主要通过 C 反应蛋白（CRP）评估，与肺功能受损有关。很少有研究探讨 CRP、血液嗜酸性粒细胞和血液中性粒细胞是否与肺功能相关，并提供额外的信息。
分析肺功能与 CRP、血液嗜酸性粒细胞和血液中性粒细胞之间的相关性，特别关注组合这些炎症标志物是否提供额外信息。
横断面研究纳入了来自全国健康和营养调查的 7753 名 20-80 岁的参与者。根据 CRP、血液嗜酸性粒细胞和血液中性粒细胞的性别三分位数，分析它们与以下肺功能参数的关系：1 秒用力呼气量占预计值的百分比（FEV%pred）、用力肺活量占预计值的百分比（FVC%pred）和 FEV/FVC 比值。
CRP、血液嗜酸性粒细胞和血液中性粒细胞水平与 FEV 和 FVC 呈负相关。只有血液嗜酸性粒细胞和血液中性粒细胞与 FEV/FVC 比值呈负相关。此外，随着最高三分位（一个、两个或三个升高的炎症标志物与非升高标志物）中升高的炎症标志物数量的增加，发现肺功能下降（FEV 的β 系数，-2.20、-4.43 和-6.43，p 值均<0.001）和 FVC（β 系数，-1.70、-3.15 和-5.33，p 值均<0.001）。
CRP、血液嗜酸性粒细胞和血液中性粒细胞独立且可提供与普通人群中较低的 FEV 和 FVC 相关的额外信息。这表明，与单独评估生物标志物相比，组合生物标志物可提供更多信息。
