Kempny Aleksander, Dimopoulos Konstantinos, Uebing Anselm, Diller Gerhard-Paul, Rosendahl Ulrich, Belitsis George, Gatzoulis Michael A, Wort Stephen J
Adult Congenital Heart Centre and National Centre for Pulmonary Hypertension, Royal Brompton Hospital, Imperial College London, London, United Kingdom.
Adult Congenital and Valvular Heart Disease Centre, Department of Cardiology and Angiology, University Hospital Muenster, Muenster, Germany.
PLoS One. 2017 Jun 19;12(6):e0178963. doi: 10.1371/journal.pone.0178963. eCollection 2017.
The number of patients with congenital heart disease (CHD) is increasing worldwide and most of them will require cardiac surgery, once or more, during their lifetime. The total volume of cardiac surgery in CHD patients at a national level and the associated mortality and predictors of death associated with surgery are not known. We aimed to investigate the surgical volume and associated mortality in CHD patients in England.
Using a national hospital episode statistics database, we identified all CHD patients undergoing cardiac surgery in England between 1997 and 2015.
We evaluated 57,293 patients (median age 11.9years, 46.7% being adult, 56.7% female). There was a linear increase in the number of operations performed per year from 1,717 in 1997 to 5,299 performed in 2014. The most common intervention at the last surgical event was an aortic valve procedure (9,276; 16.2%), followed by repair of atrial septal defect (9,154; 16.0%), ventricular septal defect (7,746; 13.5%), tetralogy of Fallot (3,523; 6.1%) and atrioventricular septal defect (3,330; 5.8%) repair. Associated mortality remained raised up to six months following cardiac surgery. Several parameters were predictive of post-operative mortality, including age, complexity of surgery, need for emergency surgery and socioeconomic status. The relationship of age with mortality was "U"-shaped, and mortality was highest amongst youngest children and adults above 60 years of age.
The number of cardiac operations performed in CHD patients in England has been increasing, particularly in adults. Mortality remains raised up to 6-months after surgery and was highest amongst young children and seniors.
全球先天性心脏病(CHD)患者数量不断增加,其中大多数患者一生中需要接受一次或多次心脏手术。目前尚不清楚全国范围内CHD患者的心脏手术总量以及与之相关的死亡率和手术死亡预测因素。我们旨在调查英格兰CHD患者的手术量及相关死亡率。
利用国家医院住院统计数据库,我们确定了1997年至2015年间在英格兰接受心脏手术的所有CHD患者。
我们评估了57293例患者(中位年龄11.9岁,46.7%为成年人,56.7%为女性)。每年进行的手术数量呈线性增加,从1997年的1717例增加到2014年的5299例。最后一次手术中最常见的干预措施是主动脉瓣手术(9276例;16.2%),其次是房间隔缺损修补术(9154例;16.0%)、室间隔缺损修补术(7746例;13.5%)、法洛四联症修补术(3523例;6.1%)和房室间隔缺损修补术(3330例;5.8%)。心脏手术后相关死亡率在术后六个月内一直居高不下。几个参数可预测术后死亡率,包括年龄、手术复杂性、急诊手术需求和社会经济状况。年龄与死亡率的关系呈“U”形,最年幼的儿童和60岁以上的成年人死亡率最高。
英格兰CHD患者的心脏手术数量一直在增加,尤其是在成年人中。术后6个月内死亡率仍然较高,最年幼的儿童和老年人死亡率最高。