Johnson Eric A, Zubair M Mujeeb, Armsby Laurie R, Burch Grant H, Good Milon K, Lasarev Michael R, Hohimer A Roger, Muralidaran Ashok, Langley Stephen M
Division of Pediatric Cardiology, Doernbecher Children's Hospital, Oregon Health & Science University (OHSU), 3181 S.W. Sam Jackson Park Rd., Portland, OR, 97239, USA.
Division of Pediatric Cardiothoracic Surgery, Doernbecher Children's Hospital, Oregon Health & Science University (OHSU), 3181 S.W. Sam Jackson Park Rd., Portland, OR, 97239, USA.
Pediatr Cardiol. 2016 Mar;37(3):593-600. doi: 10.1007/s00246-015-1319-x. Epub 2016 Jan 7.
Historically, the primary marker of quality for congenital cardiac surgery has been postoperative mortality. The purpose of this study was to determine whether additional markers (10 surgical metrics) independently predict length of stay (LOS), thereby providing specific targets for quality improvement. Ten metrics (unplanned ECMO, unplanned cardiac catheterization, revision of primary repair, delayed closure, mediastinitis, reexploration for bleeding, complete heart block, vocal cord paralysis, diaphragm paralysis, and change in preoperative diagnosis) were defined in 2008 and subsequently collected from 1024 consecutive index congenital cardiac cases, yielding 990 cases. Four patient characteristics and 22 case characteristics were used for risk adjustment. Univariate and multivariable analyses were used to determine independent associations between each metric and postoperative LOS. Increased LOS was independently associated with revision of the primary repair (p = 0.014), postoperative complete heart block requiring a permanent pacemaker (p = 0.001), diaphragm paralysis requiring plication (p < 0.001), and unplanned postoperative cardiac catheterization (p < 0.001). Compared with patients without each metric, LOS was 1.6 (95 % CI 1.1-2.2, p = 0.014), 1.7 (95 % CI 1.2-2.3, p = 0.001), 1.8 (95 % CI 1.4-2.3, p < 0.001), and 2.0 (95 % CI 1.7-2.4, p < 0.001) times as long, respectively. These effects equated to an additional 4.5-7.8 days in hospital, depending on the metric. The other 6 metrics were not independently associated with increased LOS. The quality of surgery during repair of congenital heart disease affects outcomes. Reducing the incidence of these 4 specific surgical metrics may significantly decrease LOS in this population.
从历史上看,先天性心脏手术质量的主要指标一直是术后死亡率。本研究的目的是确定其他指标(10个手术指标)是否能独立预测住院时间(LOS),从而为质量改进提供具体目标。2008年定义了10个指标(非计划性体外膜肺氧合[ECMO]、非计划性心导管插入术、初次修复术的修订、延迟闭合、纵隔炎、再次开胸止血、完全性心脏传导阻滞、声带麻痹、膈神经麻痹以及术前诊断的改变),随后从1024例连续的先天性心脏病索引病例中收集数据,最终得到990例病例。使用4个患者特征和22个病例特征进行风险调整。采用单变量和多变量分析来确定每个指标与术后住院时间之间的独立关联。住院时间延长与初次修复术的修订(p = 0.014)、需要永久性起搏器的术后完全性心脏传导阻滞(p = 0.001)、需要折叠术的膈神经麻痹(p < 0.001)以及非计划性术后心导管插入术(p < 0.001)独立相关。与没有这些指标的患者相比,住院时间分别延长了1.6倍(95%可信区间1.1 - 2.2,p = 0.014)、1.7倍(95%可信区间1.2 - 2.3,p = 0.001)、1.8倍(95%可信区间1.4 - 2.3,p < 0.001)和2.0倍(95%可信区间1.7 - 2.4,p < 0.001)。根据指标不同,这些影响相当于住院时间额外增加4.5 - 7.8天。其他6个指标与住院时间延长无独立关联。先天性心脏病修复手术期间的手术质量会影响治疗结果。降低这4个特定手术指标的发生率可能会显著缩短该人群的住院时间。