Hull M T, Warfel K A
Am J Surg Pathol. 1986 Aug;10(8):553-9. doi: 10.1097/00000478-198608000-00005.
Ten cases of glycogen-rich clear cell carcinoma of the breast are described. Only two previous case reports have been published. These neoplasms are composed of clear cells with abundant glycogen. Ultrastructurally, two cases showed large quantities of non-membrane-bound glycogen and numerous empty glycogen lakes. neoplastic cells formed tight junctions, immature desmosomes, and occasionally had short microvilli. In nine cases the glycogen-rich carcinoma grew in a solid pattern only, while one case had both solid and papillary patterns. One case was associated with a signet-ring cell carcinoma. Seven of nine patients who underwent axillary dissections had nodal metastases. Five patients died with residual disease, and one is currently alive with local skin recurrence. These data suggest that glycogen-rich clear cell carcinoma is associated with frequent lymph node metastases and mortality.
本文描述了10例乳腺富含糖原的透明细胞癌。此前仅发表过两篇病例报告。这些肿瘤由富含糖原的透明细胞组成。超微结构上，两例显示有大量无膜包绕的糖原和众多空的糖原湖。肿瘤细胞形成紧密连接、未成熟的桥粒，偶尔有短微绒毛。9例中，富含糖原的癌仅呈实性生长模式，而1例同时有实性和乳头状模式。1例与印戒细胞癌相关。9例行腋窝清扫术的患者中，7例有淋巴结转移。5例患者死于残留疾病，1例目前存活但有局部皮肤复发。这些数据表明，富含糖原的透明细胞癌常伴有淋巴结转移和死亡。
