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从藤黄科植物思茅藤树皮中分离得到的两个新的紫檀烷酮及细胞毒性。

Two new xanthones and cytotoxicity from the bark of Garcinia schomburgkiana.

机构信息

Center of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.

Natural Products Research Section, Research Division, National Cancer Institute, Bangkok, 10400, Thailand.

出版信息

J Nat Med. 2019 Jan;73(1):257-261. doi: 10.1007/s11418-018-1240-8. Epub 2018 Aug 31.

DOI:10.1007/s11418-018-1240-8
PMID:30171417
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6326088/
Abstract

Two new xanthone derivatives, named schomburgones A (1) and B (2), along with eight known compounds, including xanthones (3-8) and anthraquinones (9-10) were isolated from the bark of Garcinia schomburgkiana. Their structures were determined by spectroscopic analysis especially 1D and 2D NMR spectroscopies. All isolated compounds were evaluated for their cytotoxicity against five cancer cell lines (KB, HeLa S-3, HT-29, MCF-7 and HepG-2). Compounds 3-6 and 8 showed good cytotoxicity against all the five cancer cell lines with IC values in the range of 1.45-9.46 µM.

摘要

从思茅藤（ Garcinia schomburgkiana ）树皮中分离得到两个新的黄烷酮衍生物，命名为 schomburgones A（1）和 B（2），以及 8 个已知化合物，包括黄烷酮（3-8）和蒽醌（9-10）。通过光谱分析，特别是 1D 和 2D NMR 光谱，确定了它们的结构。所有分离得到的化合物均进行了细胞毒性评价，针对 5 种癌细胞系（KB、HeLa S-3、HT-29、MCF-7 和 HepG-2）。化合物 3-6 和 8 对所有 5 种癌细胞系均表现出良好的细胞毒性，IC 值范围为 1.45-9.46μM。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e62/6326088/8d4970f5bc63/11418_2018_1240_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e62/6326088/dae4ce18aa4d/11418_2018_1240_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e62/6326088/8d4970f5bc63/11418_2018_1240_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e62/6326088/dae4ce18aa4d/11418_2018_1240_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e62/6326088/8d4970f5bc63/11418_2018_1240_Fig2_HTML.jpg

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