Doğanay Yıldız Ezgi, Arslan Hakan, Köseoğlu Serhat, Arabacı Taner, Yıldız Dursun Anıl, Savran Levent
Department of Endodontics, Faculty of Dentistry, Kırıkkale University, Kırıkkale, Turkey.
Department of Endodontics, Faculty of Dentistry, Ataturk University, Erzurum, Turkey.
Lasers Med Sci. 2019 Apr;34(3):517-523. doi: 10.1007/s10103-018-2625-3. Epub 2018 Aug 31.
To investigate the effect of photobiomodulation (PBM) and placebo on total amount of substance P in gingival crevicular fluid (GCF) pre- and postoperatively. Twenty-six patients having tooth with symptomatic apical periodontitis were enrolled in this study. GCF was collected preoperatively. The patients were assigned into two groups (n = 13), as follows: placebo and PBM. Sampling was repeated 7 days after root canal treatment. Two independent samples T test was used for analyzing of the differences between preoperative and postoperative substance P levels in GCF (p = .05). The Pearson correlation analysis was used for determination of correlation among substance P levels and other variables. For placebo group, there is no significant difference between preoperative and postoperative total amounts of substance P level (p = 0.553). For PBM group, postoperative total amount of substance P level was significantly higher than those of preoperative level (p = 0.005). Within the limitation of the present study, PBM has immunomodulation effect linked to the modulation of the total amount of substance P in the gingival crevicular fluid. Thai Clinical Trials Registry: TCTR20161228002.
为研究光生物调节（PBM）和安慰剂对龈沟液（GCF）中P物质总量在术前和术后的影响。本研究纳入了26例患有症状性根尖周炎牙齿的患者。术前收集龈沟液。患者被分为两组（n = 13），如下：安慰剂组和PBM组。根管治疗7天后重复采样。采用两独立样本T检验分析龈沟液中术前和术后P物质水平的差异（p = 0.05）。采用Pearson相关分析确定P物质水平与其他变量之间的相关性。对于安慰剂组，术前和术后P物质水平总量无显著差异（p = 0.553）。对于PBM组，术后P物质水平总量显著高于术前水平（p = 0.005）。在本研究的局限性内，PBM具有与龈沟液中P物质总量调节相关的免疫调节作用。泰国临床试验注册中心：TCTR20161228002。
