猪细胞色素 2A19 和 2E1。
Porcine cytochrome 2A19 and 2E1.
机构信息
Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, University of South Bohemia in Ceske Budejovice, Vodnany, Czech Republic.
Department of Molecular Science, Swedish University of Agricultural Sciences, Uppsala, Sweden.
出版信息
Basic Clin Pharmacol Toxicol. 2019 Jan;124(1):32-39. doi: 10.1111/bcpt.13121. Epub 2018 Oct 4.
Abstract
Cytochrome P450 (CYP) is a major group of enzymes, which conduct Phase I metabolism. Among commonly used animal models, the pig has been suggested as the most suitable model for investigating drug metabolism in human beings. Moreover, porcine CYP2A19 and CYP2E1 are responsible for the biotransformation of both endogenous and exogenous compounds such as 3-methylindole (skatole), sex hormones and food compounds. However, little is known about the regulation of porcine CYP2A19 and CYP2E1. In this MiniReview, we summarise the current knowledge about the regulation of porcine CYP2A19 and CYP2E1 by environmental, biological and dietary factors. Finally, we reflect on the need for further research, to clarify the interaction between active feed components and the porcine CYP system.
摘要
细胞色素 P450（CYP）是一个主要的酶类群体，进行 I 相代谢。在常用的动物模型中，猪被认为是研究人类药物代谢最适合的模型。此外，猪 CYP2A19 和 CYP2E1 负责生物转化内源性和外源性化合物，如 3-甲基吲哚（粪臭素）、性激素和食物化合物。然而，关于猪 CYP2A19 和 CYP2E1 的调控机制知之甚少。在这篇综述中，我们总结了目前关于环境、生物和饮食因素对猪 CYP2A19 和 CYP2E1 调控的认识。最后，我们反思了需要进一步研究，以阐明活性饲料成分与猪 CYP 系统之间的相互作用。
相似文献
1
Porcine cytochrome 2A19 and 2E1.猪细胞色素 2A19 和 2E1。
Basic Clin Pharmacol Toxicol. 2019 Jan;124(1):32-39. doi: 10.1111/bcpt.13121. Epub 2018 Oct 4.
2
Porcine CYP2A19, CYP2E1 and CYP1A2 forms are responsible for skatole biotransformation in the reconstituted system.猪的CYP2A19、CYP2E1和CYP1A2亚型在重组系统中负责粪臭素的生物转化。
Neuro Endocrinol Lett. 2009;30 Suppl 1:36-40.
3
End-product inhibition of skatole-metabolising enzymes CYP1A, CYP2A19 and CYP2E1 in porcine and piscine hepatic microsomes.
Toxicol Lett. 2019 Mar 15;303:67-71. doi: 10.1016/j.toxlet.2018.12.017. Epub 2018 Dec 30.
4
The roles of different porcine cytochrome P450 enzymes and cytochrome b5A in skatole metabolism.不同猪细胞色素 P450 酶和细胞色素 b5A 在粪臭素代谢中的作用。
Animal. 2012 May;6(5):834-45. doi: 10.1017/S1751731111002175.
5
2-Oxidation, 3-methyl hydroxylation, and 6-hydroxylation of skatole, a contributor to the odour of boar-tainted pork meat, mediated by porcine liver microsomal cytochromes P450 1A2, 2A19, 2E1, and 3A22.猪肝脏微粒体细胞色素P450 1A2、2A19、2E1和3A22介导的粪臭素（导致公猪异味猪肉气味的一种物质）的2-氧化、3-甲基羟基化和6-羟基化反应。
Xenobiotica. 2023 Jan;53(1):60-65. doi: 10.1080/00498254.2023.2197037. Epub 2023 Apr 5.
6
The role of CYP2A and CYP2E1 in the metabolism of 3-methylindole in primary cultured porcine hepatocytes.CYP2A和CYP2E1在原代培养猪肝细胞中对3-甲基吲哚代谢的作用。
Drug Metab Dispos. 2006 May;34(5):848-54. doi: 10.1124/dmd.105.008128. Epub 2006 Feb 24.
7
Cloning and mapping of the porcine cytochrome-p450 2E1 gene and its association with skatole levels in the domestic pig.猪细胞色素P450 2E1基因的克隆、定位及其与家猪粪臭素水平的关联
Anim Genet. 2005 Oct;36(5):417-22. doi: 10.1111/j.1365-2052.2005.01342.x.
8
Functional polymorphism in porcine CYP2E1 gene: Its association with skatole levels.
J Steroid Biochem Mol Biol. 2006 Jun;99(4-5):231-7. doi: 10.1016/j.jsbmb.2005.07.001.
9
Metabolism of 3-methylindole by porcine liver microsomes: responsible cytochrome P450 enzymes.
Toxicol Sci. 2000 Jun;55(2):284-92. doi: 10.1093/toxsci/55.2.284.
10
Skatole metabolites in urine as a biological marker of pigs with enhanced hepatic metabolism.尿液中的粪臭素代谢产物作为肝脏代谢增强的猪的生物标志物。
Animal. 2016 Oct;10(10):1734-40. doi: 10.1017/S1751731116000574. Epub 2016 Apr 15.
引用本文的文献
1
Hepatic Gene Expression and Metabolite Profiles of Androstenone and Skatole Relative to Plasma Estrone Sulfate Levels in Boars.公猪血浆雌酮硫酸酯水平与雄甾酮和粪臭素的肝基因表达和代谢谱的关系。
Biomolecules. 2024 Jul 15;14(7):850. doi: 10.3390/biom14070850.
2
Influence of Different Plant Extracts on CYP-Mediated Skatole and Indole Degradation in Pigs.不同植物提取物对猪体内细胞色素P450介导的粪臭素和吲哚降解的影响
Animals (Basel). 2024 Mar 13;14(6):888. doi: 10.3390/ani14060888.
3
Quantitative Proteomic Analysis of Tibetan Pig Livers at Different Altitudes.不同海拔藏猪肝脏的定量蛋白质组学分析。
Molecules. 2023 Feb 10;28(4):1694. doi: 10.3390/molecules28041694.
4
Aflatoxins in Feed: Types, Metabolism, Health Consequences in Swine and Mitigation Strategies.饲料中的黄曲霉毒素：类型、代谢、对猪的健康影响及缓解策略。
Toxins (Basel). 2022 Dec 3;14(12):853. doi: 10.3390/toxins14120853.
5
Nuclear Receptor Pathways Mediating the Development of Boar Taint.介导公猪膻味产生的核受体信号通路
Metabolites. 2022 Aug 25;12(9):785. doi: 10.3390/metabo12090785.
6
Hepatic Cytochrome P450 Abundance and Activity in the Developing and Adult Göttingen Minipig: Pivotal Data for PBPK Modeling.发育中和成年哥廷根小型猪肝脏细胞色素P450的丰度和活性：用于生理药代动力学（PBPK）建模的关键数据。
Front Pharmacol. 2021 Apr 15;12:665644. doi: 10.3389/fphar.2021.665644. eCollection 2021.
7
The Effectiveness of Dietary Byproduct Antioxidants on Induced CYP Genes Expression and Histological Alteration in Piglets Liver and Kidney Fed with Aflatoxin B1 and Ochratoxin A.日粮副产品抗氧化剂对采食黄曲霉毒素 B1 和赭曲霉毒素 A 的仔猪肝脏和肾脏中 CYP 基因表达及组织学变化的影响
Toxins (Basel). 2021 Feb 15;13(2):148. doi: 10.3390/toxins13020148.
8
The Neonatal and Juvenile Pig in Pediatric Drug Discovery and Development.儿科药物研发中的新生和幼年猪
Pharmaceutics. 2020 Dec 30;13(1):44. doi: 10.3390/pharmaceutics13010044.
本文引用的文献
1
Skeletal Muscle Interleukin-6 Regulates Hepatic Cytochrome P450 Expression: Effects of 16-Week High-Fat Diet and Exercise.骨骼肌白细胞介素-6 调节肝细胞色素 P450 表达：16 周高脂肪饮食和运动的影响。
Toxicol Sci. 2018 Mar 1;162(1):309-317. doi: 10.1093/toxsci/kfx258.
2
Quercetin prevents type 1 diabetic liver damage through inhibition of CYP2E1.槲皮素通过抑制 CYP2E1 预防 1 型糖尿病肝损伤。
Pharmacol Rep. 2017 Dec;69(6):1386-1392. doi: 10.1016/j.pharep.2017.05.020. Epub 2017 Jun 24.
3
The effect of quercetin on the pharmacokinetics of chlorzoxazone, a CYP2E1 substrate, in healthy subjects.槲皮素对CYP2E1底物氯唑沙宗在健康受试者体内药代动力学的影响。
Eur J Clin Pharmacol. 2018 Jan;74(1):91-97. doi: 10.1007/s00228-017-2345-9. Epub 2017 Oct 5.
4
Comparison of In Vitro Hepatic Scoparone 7-O-Demethylation between Humans and Experimental Animals.人类与实验动物体外滨蒿内酯7-O-去甲基化的比较
Planta Med. 2018 Mar;84(5):320-328. doi: 10.1055/s-0043-119886. Epub 2017 Sep 26.
5
Activation of the aryl hydrocarbon receptor decreases rifampicin-induced CYP3A4 expression in primary human hepatocytes and HepaRG.芳烃受体的激活降低了利福平诱导的原代人肝细胞和HepaRG细胞中CYP3A4的表达。
Toxicol Lett. 2017 Aug 5;277:1-8. doi: 10.1016/j.toxlet.2017.05.029. Epub 2017 May 29.
6
A systematic evaluation of microRNAs in regulating human hepatic CYP2E1.对微小RNA调控人类肝脏CYP2E1的系统评价。
Biochem Pharmacol. 2017 Aug 15;138:174-184. doi: 10.1016/j.bcp.2017.04.020. Epub 2017 Apr 22.
7
In vitro inhibition of human CYP2E1 and CYP3A by quercetin and myricetin in hepatic microsomes is not gender dependent.槲皮素和杨梅素在肝微粒体中对人CYP2E1和CYP3A的体外抑制作用不存在性别依赖性。
Toxicology. 2017 Apr 15;381:10-18. doi: 10.1016/j.tox.2017.02.012. Epub 2017 Feb 21.
8
Constitutive expression and activity of cytochrome P450 in conventional pigs.普通猪中细胞色素P450的组成型表达与活性
Res Vet Sci. 2017 Apr;111:75-80. doi: 10.1016/j.rvsc.2016.12.003. Epub 2016 Dec 23.
9
Hydrolysable tannin-based diet rich in gallotannins has a minimal impact on pig performance but significantly reduces salivary and bulbourethral gland size.富含没食子单宁的可水解单宁基日粮对猪的生长性能影响极小，但会显著减小唾液腺和尿道球腺的大小。
Animal. 2017 Sep;11(9):1617-1625. doi: 10.1017/S1751731116002597. Epub 2016 Dec 22.
10
Comparison of xenobiotic-metabolising human, porcine, rodent, and piscine cytochrome P450.异生物质代谢的人类、猪、啮齿动物和鱼类细胞色素P450的比较。
Toxicology. 2017 Jan 15;375:10-27. doi: 10.1016/j.tox.2016.11.014. Epub 2016 Nov 22.
Zotero 插件