基于涂层微针的皮内免疫疗法可预防 Der p 1 诱导的小鼠气道过敏。
Coated microneedle-based cutaneous immunotherapy prevents Der p 1-induced airway allergy in mice.
机构信息
Department of Chemical Engineering, Texas Tech University, Lubbock, Tex.
Department of Chemical Engineering, Texas Tech University, Lubbock, Tex.
出版信息
J Allergy Clin Immunol. 2018 Dec;142(6):2007-2011.e3. doi: 10.1016/j.jaci.2018.08.017. Epub 2018 Aug 30.
Abstract
Der p1-coated microneedles after just three minutes of application led to efficient allergen delivery into skin and prevented development of airway allergy in a mouse. Allergen-coated microneedles may have potential for minimally-invasive allergen vaccination and immunotherapy.
摘要
经皮 p1 涂层微针在给药 3 分钟后，可有效将变应原递送至皮肤，并预防小鼠气道过敏的发生。变应原涂层微针具有微创变应原疫苗接种和免疫治疗的潜力。
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