Li Jiaqi, Xia Qing, Ma Shuwen, Wang Zhi, Guo Teng, Feng Nianping, Zhang Yongtai
Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Asian J Pharm Sci. 2025 Jun;20(3):101051. doi: 10.1016/j.ajps.2025.101051. Epub 2025 Mar 28.
Microneedle-mediated drug delivery systems (MDDS) have experienced robust growth in recent years, with designers leveraging their creativity to apply these systems for direct drug delivery to the skin, mucous membranes, blood vessel walls and even internal organs. In order to achieve precise drug delivery, various delicately conceived drug release modes based on MDDS have been developed. Herein, to elucidate the design concepts of numerous reported MDDS, we have categorized them into two levels (Level-Ⅰ MDDS and Level-Ⅱ MDDS) depending on whether nanoscale and microscale carriers are integrated within the microneedles. In this work, the design strategies of MDDS, as well as the current status of their applications in targeted and intelligent drug delivery were reviewed, while their prospects and challenges for future industrialization and clinical applications were also discussed.
近年来，微针介导的药物递送系统（MDDS）发展迅速，设计者发挥创造力，将这些系统应用于药物直接递送至皮肤、粘膜、血管壁甚至内部器官。为了实现精确的药物递送，基于MDDS开发了各种精心设计的药物释放模式。在此，为阐明众多已报道的MDDS的设计理念，我们根据微针内是否整合了纳米级和微米级载体，将它们分为两个级别（Ⅰ级MDDS和Ⅱ级MDDS）。在这项工作中，我们综述了MDDS的设计策略及其在靶向和智能药物递送中的应用现状，同时也讨论了它们未来产业化和临床应用的前景与挑战。
