Departments of Anesthesiology and Perioperative Medicine and Pharmacology, Penn State College of Medicine, Hershey, PA, 17033 USA; Neuroscience graduate program, Penn State College of Medicine, Hershey, PA, 17033 USA.
Departments of Anesthesiology and Perioperative Medicine and Pharmacology, Penn State College of Medicine, Hershey, PA, 17033 USA.
Pharmacol Res. 2018 Oct;136:90-96. doi: 10.1016/j.phrs.2018.08.025. Epub 2018 Aug 29.
The compulsive drive to seek drugs despite negative consequences relies heavily on drug-induced alterations that occur within the reward neurocircuit. These alterations include changes in neuromodulator and neurotransmitter systems that ultimately lock behaviors into an inflexible and permanent state. To provide clinicians with improved treatment options, researchers are trying to identify, as potential targets of therapeutic intervention, the neural mechanisms mediating an "addictive-like state". Here, we discuss how drug-induced generation of silent synapses in the nucleus accumbens may be a potential therapeutic target capable of reversing drug-related behaviors.
尽管存在负面后果，但人们仍会强迫性地寻求毒品，这主要依赖于药物在奖励神经回路中引起的改变。这些改变包括神经调质和神经递质系统的变化，最终将行为锁定在一种僵化和永久的状态。为了为临床医生提供更好的治疗选择，研究人员正在努力寻找潜在的治疗靶点，即介导“成瘾样状态”的神经机制。在这里，我们讨论了药物诱导伏隔核中沉默突触的产生如何成为一个潜在的治疗靶点，能够逆转与药物相关的行为。
