Department of Child and Adolescent Psychiatry, Erasmus MC, Sophia Children's Hospital, 3000 CB Rotterdam, the Netherlands; Department of Psychology, Education and Child Studies, Erasmus University Rotterdam, 3000 DR Rotterdam, the Netherlands; Department of Pediatrics, Erasmus MC, Sophia Children's Hospital, 3000 CB Rotterdam, the Netherlands.
School of Social Work, Rutgers University, 536 George Street, New Brunswick, NJ 08901, USA; Department of Urban-Global Public Health, School of Public Health, Rutgers University, 683 Hoes Lane West, Piscataway, NJ 08854, USA; Center for Prevention Science, School of Social Work, Rutgers University, 390 George Street, New Brunswick, NJ 08901, USA.
Prev Med. 2018 Nov;116:1-5. doi: 10.1016/j.ypmed.2018.08.036. Epub 2018 Aug 29.
The objective of the current narrative literature review is to provide an epidemiological, developmental and clinical overview on cannabis use during pregnancy. Cannabis use in pregnancy poses major health concerns for pregnant mothers and their developing children. Although studies on the short- and long-term consequences of prenatal cannabis exposure are increasing, findings have been inconsistent or difficult to interpret due to methodological issues. Thus, consolidating these findings into clinical recommendations based on the mixed studies in the literature remains a challenge. Synthesizing the available observational studies is also difficult, because some of the published studies have substantial methodological weaknesses. Improving observational studies will be an important step toward understanding the extent to which prenatal exposure to cannabis influences neurodevelopment in the offspring. Therefore, further research on prenatal cannabis exposure and the long-term consequences to offspring health in representative samples are needed to guide and improve clinical care for pregnant women and their children. Future research should also investigate the role of policies on prenatal cannabis use.
本叙述性文献综述的目的在于提供有关怀孕期间使用大麻的流行病学、发展和临床概述。怀孕期间使用大麻会给孕妇及其发育中的子女带来重大健康问题。尽管越来越多的研究关注产前大麻暴露的短期和长期后果，但由于方法学问题，研究结果一直存在不一致或难以解释的情况。因此，根据文献中的混合研究，将这些发现整合为临床建议仍然是一个挑战。由于一些已发表的研究存在严重的方法学缺陷，因此综合现有观察性研究也具有一定难度。提高观察性研究将是理解产前接触大麻在多大程度上影响后代神经发育的重要一步。因此，需要进一步研究代表性样本中产前接触大麻与后代健康的长期后果，以指导和改善孕妇及其子女的临床护理。未来的研究还应调查关于产前使用大麻的政策的作用。
