发育过程中同时暴露于酒精和大麻：机制和结果。
Combined exposure to alcohol and cannabis during development: Mechanisms and outcomes.
机构信息
Departamento de Psicologia, Laboratório de Neurociência do Comportamento, Pontifícia Universidade Católica do Rio de Janeiro, Rua Marquês de São Vicente, 225, Gávea - Rio de Janeiro, RJ, 22451-900, Brazil.
Department of Pediatrics - School of Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, United States.
出版信息
Alcohol. 2023 Aug;110:1-13. doi: 10.1016/j.alcohol.2023.01.004. Epub 2023 Feb 3.
Exposure to substances of abuse during pregnancy can have long-lasting effects on offspring. Alcohol is one of the most widely used substances of abuse that leads to the most severe consequences. Recent studies in the United States, Canada, and the United Kingdom showed that between 1% and 7% of all children exhibit signs and symptoms of fetal alcohol spectrum disorder (FASD). Despite preventive campaigns, the rate of children with FASD has not decreased during recent decades. Alcohol consumption often accompanies exposure to such drugs as tobacco, cocaine, opioids, and cannabis. These interactions can be synergistic and exacerbate the deleterious consequences of developmental alcohol exposure. The present review focuses on interactions between alcohol and cannabis exposure and the potential consequences of these interactions.
怀孕期间接触滥用物质会对后代产生持久影响。酒精是最广泛使用的滥用物质之一，会导致最严重的后果。最近在美国、加拿大和英国的研究表明，所有儿童中有 1%至 7%表现出胎儿酒精谱系障碍 (FASD) 的迹象和症状。尽管开展了预防运动，但近几十年来，患有 FASD 的儿童比例并未下降。饮酒者通常同时接触烟草、可卡因、阿片类药物和大麻等药物。这些相互作用可能具有协同作用，并加剧发育性酒精暴露的有害后果。本综述重点关注酒精和大麻暴露之间的相互作用以及这些相互作用的潜在后果。
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