Department of Occupational Health and Environmental Hygiene, School of Public Health, Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang 550025, Guizhou, China.
Department of Occupational Health and Environmental Hygiene, School of Public Health, Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang 550025, Guizhou, China.
Environ Toxicol Pharmacol. 2018 Oct;63:60-68. doi: 10.1016/j.etap.2018.08.011. Epub 2018 Aug 18.
Fluorine and aluminium are nervous system poisons, but it remains unclear whether combined fluorine and aluminium exposure damages spatial learning and memory and, if so, by what mechanism. This study showed that exposure to fluorine and aluminium, either alone or combined, during the embryonic stage and into adulthood caused spatial learning and memory impairment in offspring rats; its mechanism may be associated with increases in miR-132 and miR-204 expression and downregulation of the BDNF-TrkB pathway in the hippocampus. The effects of F were obvious, but the effects of Al were slight. There were antagonistic effects between F and Al, with Al reducing the toxicity of F.
氟和铝是神经系统毒物，但氟铝联合暴露是否损害空间学习记忆及其机制仍不清楚。本研究显示，胚胎期及成年期暴露于氟和铝，无论是单独暴露还是联合暴露，均可导致仔鼠空间学习记忆损伤；其机制可能与海马内 miR-132 和 miR-204 表达增加和 BDNF-TrkB 通路下调有关。氟的作用明显，而铝的作用轻微。氟和铝之间存在拮抗作用，铝可降低氟的毒性。
