Clinic for Animal Reproduction, Faculty of Veterinary Medicine, Freie Universität Berlin, Koenigsweg 65, 14163 Berlin, Germany.
Clinic for Animal Reproduction, Faculty of Veterinary Medicine, Freie Universität Berlin, Koenigsweg 65, 14163 Berlin, Germany.
J Dairy Sci. 2018 Nov;101(11):10557-10564. doi: 10.3168/jds.2018-14933. Epub 2018 Aug 30.
The objective of the study was to update a prior meta-analysis on the efficacy of the treatment of bovine endometritis with PGF. Clinical endometritis in cattle is defined as the presence of a purulent or mucopurulent vaginal discharge after 20 or 26 d, respectively, postpartum. Although the prevalence and impact of this disease are well known, the questions of whether and how to treat endometritis are still controversially discussed. Hence, to ensure timeliness of scientific results, we updated an existing meta-analysis published in 2013 that showed no treatment effect of PGF in cases of bovine endometritis. As in the prior meta-analysis, a comprehensive literature search was conducted. After applying specific inclusion and exclusion criteria, 3 trials remained that could be added to the 6 trials in the initial meta-analysis. Data for each trial were analyzed using the meta-analysis software Review Manager (version 5.3; The Nordic Cochrane Centre, Copenhagen, Denmark). Estimated effect sizes of PGF were calculated on calving to first service interval (CFSI) and calving to conception interval (CCI). As revealed by the initial meta-analysis, PGF treatment still had no effect on both reproductive parameters. Heterogeneity remained substantial for CFSI and CCI and even increased for CCI compared with the initial meta-analysis. Subgroup analysis, however, did not reveal a source of heterogeneity. In updating the meta-analysis, publication bias for trials reporting CCI became even more pronounced, suggesting that studies with higher standard error (i.e., usually smaller studies) that reported a prolonging effect on CCI after a PGF treatment were less likely to be published. Finally, although the number of trials published on the chosen topic and their comparability are still limited, this update of our meta-analysis now provides results that are based on approximately twice the number of included cows. The overall outcome, however, has not substantially changed and a positive effect of a PGF treatment in case of clinical endometritis could not be shown. Therefore, we do not recommend a treatment of bovine endometritis with PGF as a means to improve reproductive performance.
本研究的目的是更新先前关于 PGF 治疗牛子宫内膜炎疗效的荟萃分析。牛临床型子宫内膜炎的定义为产后 20 或 26 天分别出现化脓性或粘液脓性阴道分泌物。尽管这种疾病的流行率和影响众所周知，但关于是否以及如何治疗子宫内膜炎的问题仍存在争议。因此，为了确保科学结果的及时性，我们更新了 2013 年发表的一项先前的荟萃分析，该分析表明 PGF 对牛子宫内膜炎没有治疗作用。与先前的荟萃分析一样，我们进行了全面的文献检索。在应用特定的纳入和排除标准后，有 3 项试验符合要求，可以添加到最初荟萃分析中的 6 项试验中。使用荟萃分析软件 Review Manager（版本 5.3；丹麦哥本哈根北欧 Cochrane 中心）对每项试验的数据进行分析。根据产犊至首次配种间隔（CFSI）和产犊至受胎间隔（CCI）计算 PGF 的估计效应大小。正如最初的荟萃分析所示，PGF 治疗对这两个生殖参数仍没有影响。CFSI 和 CCI 的异质性仍然很大，与最初的荟萃分析相比，CCI 的异质性甚至增加。但是，亚组分析并未发现异质性的来源。在更新荟萃分析时，报告 CCI 的试验的发表偏倚变得更加明显，这表明在接受 PGF 治疗后报告 CCI 延长的研究，由于标准误差较高（即通常是较小的研究），更不可能被发表。最后，尽管关于所选主题的试验数量及其可比性仍然有限，但我们的荟萃分析更新现在提供了基于大约两倍纳入牛数量的结果。然而，总体结果并没有发生实质性变化，也无法证明 PGF 治疗在临床型子宫内膜炎中的积极作用。因此，我们不建议使用 PGF 治疗牛子宫内膜炎来提高繁殖性能。
