Zhou Xiaoyan, Wang Pengli, Zhao Hui
Department of Oncology, Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, China.
Department of General Surgery, Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, China.
Front Physiol. 2018 Aug 17;9:1124. doi: 10.3389/fphys.2018.01124. eCollection 2018.
The Aurora kinase A (AURKA) gene is frequently amplified and overexpressed in gastric cancer (GC). The overexpression of AURKA promotes inflammation and tumorigenesis in GC. We performed co-expression analysis to identify genes associated with AURKA and speculated its function through the COXPRESdb and STRING databases. We also conducted a hospital-based case-control study involving 385 GC cases and 470 controls in a Chinese population to evaluate the role of AURKA gene rs2273535 polymorphism in the risk of GC. Genotyping was performed using a custom-by-design 48-Plex single nucleotide polymorphism (SNP) Scan™ Kit. Co-expression analysis indicated that the overexpression of AURKA may be associated with poor prognosis of GC. In addition, TT genotypes of rs2273535 polymorphism increased the risk of GC by 72% compared to the AA genotypes. This significant correlation was also observed in the allelic and dominant models. The stratified analysis suggested that TT+AT genotypes showed positive correlation with the risk of GC among female, age <55 years group and non-smokers compared to AA genotypes. In conclusion, AURKA plays an important role in the development of GC. Larger studies with more diverse ethnic populations are needed to confirm these results.
极光激酶A（AURKA）基因在胃癌（GC）中经常发生扩增和过表达。AURKA的过表达促进了胃癌中的炎症和肿瘤发生。我们进行了共表达分析以鉴定与AURKA相关的基因，并通过COXPRESdb和STRING数据库推测其功能。我们还在中国人群中开展了一项基于医院的病例对照研究，涉及385例胃癌病例和470例对照，以评估AURKA基因rs2273535多态性在胃癌风险中的作用。使用定制的48重单核苷酸多态性（SNP）扫描™试剂盒进行基因分型。共表达分析表明，AURKA的过表达可能与胃癌的预后不良有关。此外，与AA基因型相比，rs2273535多态性的TT基因型使胃癌风险增加了72%。在等位基因和显性模型中也观察到了这种显著相关性。分层分析表明，与AA基因型相比，TT + AT基因型在女性、年龄<55岁组和非吸烟者中与胃癌风险呈正相关。总之，AURKA在胃癌的发生发展中起重要作用。需要开展更多涉及更多不同种族人群的研究来证实这些结果。
