Arora R C, Meltzer H Y
Department of Psychiatry, Case Western Reserve University, School of Medicine, Cleveland, OH 44106.
Biol Psychiatry. 1988 Feb 1;23(3):217-26. doi: 10.1016/0006-3223(88)90032-7.
Imipramine binding (IB) was studied in the blood platelets from normal controls and depressed patients over a 4-year period (1981-1984) to determine if seasonal variation was present in Bmax or KD. Bimonthly variation in the Bmax of IB was found in normal controls studied longitudinally. No such variation was found when individual values from normal controls were examined on a monthly or seasonal basis. Bmax in depressed patients showed a significant seasonal, but not monthly, variation. KD of IB varied in normal controls using monthly or seasonal data, but not in the probably more reliable bimonthly data. These results suggest that IB studies comparing groups of subjects should match groups for season of the year or, for greater accuracy, month of the year.
在1981年至1984年的4年期间，对正常对照组和抑郁症患者的血小板进行了丙咪嗪结合（IB）研究，以确定Bmax或KD是否存在季节性变化。对正常对照组进行纵向研究时发现，IB的Bmax存在双月变化。当按月或按季节检查正常对照组的个体值时，未发现此类变化。抑郁症患者的Bmax显示出显著的季节性变化，但没有月度变化。使用月度或季节性数据时，正常对照组中IB的KD有所变化，但使用可能更可靠的双月数据时则没有变化。这些结果表明，比较受试者组的IB研究应使各组在一年中的季节相匹配，或者为了更高的准确性，应使各组在一年中的月份相匹配。
