Simões-Silva Liliana, Ferreira Susana, Santos-Araujo Carla, Tabaio Margarida, Pestana Manuel, Soares-Silva Isabel, Sampaio-Maia Benedita
i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
INEB-Instituto de Engenharia Biomédica, Universidade do Porto, Rua Alfredo Allen 208, 4200-180 Porto, Portugal.
Can J Infect Dis Med Microbiol. 2018 Aug 2;2018:5789094. doi: 10.1155/2018/5789094. eCollection 2018.
Peritoneal dialysis-related infections are important morbidity/mortality causes, being staphylococci the most prevalent agents. Since nasopharynx carriage is a known risk factor for PD infections and the oral cavity is a starting point for systemic diseases development, we aimed at comparing the oral staphylococci colonization between PD patients and controls and studying the association with PD-related infections. Saliva samples were plated in Mannitol salt, and isolates were identified by gene sequencing. Staphylococci PD-related infections were recorded throughout the 4-year period following sample collection. colonization was present in >90% of the samples from both groups (a total of nine species identified). PD patients presented less diversity and less prevalence of multispecies colonization. Although all patients presenting PD-related infections were also colonized in the oral cavity by the same agent, only 1 out of 7 patients with ESI caused by . presented oral colonization. Staphylococci are highly prevalent in the oral cavity of both groups, although PD patients presented less species diversity. The association between oral carriage and PD-related infections was present for but was almost inexistent for , so, further studies are still necessary to evaluate the infectious potential of oral carriage in PD.
腹膜透析相关感染是重要的发病/死亡原因，葡萄球菌是最常见的病原体。由于鼻咽部携带是腹膜透析感染的已知危险因素，且口腔是全身性疾病发展的起始点，我们旨在比较腹膜透析患者和对照组之间口腔葡萄球菌定植情况，并研究其与腹膜透析相关感染的关联。将唾液样本接种于甘露醇盐培养基上，通过基因测序鉴定分离株。在样本采集后的4年期间记录与葡萄球菌相关的腹膜透析感染情况。两组中超过90%的样本存在定植（共鉴定出9种菌种）。腹膜透析患者的定植多样性较低，多菌种定植的发生率也较低。虽然所有发生腹膜透析相关感染的患者口腔中也被同一种病原体定植，但7例由[具体病原体名称未给出]引起的[具体感染类型未给出]患者中只有1例存在口腔定植。两组患者口腔中葡萄球菌的定植都很普遍，尽管腹膜透析患者的菌种多样性较低。口腔携带与腹膜透析相关感染之间存在关联，但[具体菌种未给出]几乎不存在这种关联，因此，仍需进一步研究以评估腹膜透析患者口腔携带的感染潜力。
