Wu Shuang, Tong Nianting, Pan Lin, Jiang Xiaohui, Li Yanan, Guo MeiLing, Li Hehuan
Qingdao Municipal Hospital Affiliated to Qingdao University, No. 5 Donghaizhong Road, Shinan District, Qingdao, Shandong, China.
Department of Ophthalmology, Qingdao Municipal Hospital, No. 5 Donghaizhong Road, Shinan District, Qingdao, Shandong, China.
J Ophthalmol. 2018 Aug 5;2018:9089285. doi: 10.1155/2018/9089285. eCollection 2018.
To evaluate the potential risk factors of posterior capsule opacification (PCO) after cataract surgery.
Data on PCO patients diagnosed from September 2015 to May 2017 were obtained from the Department of Ophthalmology at Qingdao Municipal Hospital, Qingdao, China. The factors associated with PCO were assessed using Pearson's test for univariate analyses and logistic regression for multivariate analyses.
Eyes (652) from 550 patients were enrolled in this study. All patients were diagnosed with PCO/non-PCO and had <3 years of follow-up after surgery. The numbers of PCO and non-PCO were 108 eyes and 544 eyes, respectively. Statistically significant associations with PCO were found for age at the time of surgery ( = 78.504; < 0.001), diabetes ( = 4.829; =0.028), immune diseases ( = 4.234; =0.004), high myopia ( = 5.753; =0.016), lens nucleus hardness ( = 11.046; =0.026), surgery type ( = 11.354; =0.001), a history of vitrectomy ( = 4.212; =0.004), ocular inflammation ( = 6.01; =0.009), and the intraocular lens (IOL) type ( = 8.696; =0.003). Multivariable data analyses using logistic regression analyses of the variables showed that age at the time of surgery <60 years, diabetes, lens nucleus hardness of III-V, extracapsular cataract extraction (ECCE), postvitrectomy, and hydrophilic IOLs were significant independent risk factors associated with PCO.
Age <60 years, diabetes, lens nucleus hardness of III-V, ECCE, postvitrectomy, and a hydrophilic IOL were significantly associated with the formation of PCO. Estimation of the incidence of and risk factors for PCO should help in patients counseling and in the design of treatment protocols to reduce or prevent its development.
评估白内障手术后后囊膜混浊（PCO）的潜在危险因素。
从中国青岛市政医院眼科获取2015年9月至2017年5月诊断为PCO患者的数据。使用Pearson检验进行单因素分析，使用逻辑回归进行多因素分析，评估与PCO相关的因素。
本研究纳入了550例患者的652只眼。所有患者均被诊断为PCO/非PCO，且术后随访时间<3年。PCO组和非PCO组的眼数分别为108只和544只。发现手术时年龄（χ² = 78.504；P < 0.001）、糖尿病（χ² = 4.829；P = 0.028）、免疫疾病（χ² = 4.234；P = 0.004）、高度近视（χ² = 5.753；P = 0.016）、晶状体核硬度（χ² = 11.046；P = 0.026）、手术类型（χ² = 11.354；P = 0.001）、玻璃体切割术史（χ² = 4.212；P = 0.004）、眼部炎症（χ² = 6.01；P = 0.009）和人工晶状体（IOL）类型（χ² = 8.696；P = 0.003）与PCO有统计学显著相关性。对变量进行逻辑回归分析的多变量数据分析显示，手术时年龄<60岁、糖尿病、晶状体核硬度为III-V级、白内障囊外摘除术（ECCE）、玻璃体切割术后以及亲水性IOL是与PCO相关的显著独立危险因素。
年龄<60岁、糖尿病、晶状体核硬度为III-V级、ECCE、玻璃体切割术后以及亲水性IOL与PCO的形成显著相关。对PCO发病率和危险因素的评估应有助于患者咨询以及设计治疗方案以减少或预防其发生。
