Uzun Feyzahan, Aydın Emre, Akgöz Hasan, Aslan Mehmet Gökhan
Recep Tayyip Erdogan University, School of Medicine, Department of Ophthalmology, Rize, Turkey.
J Inflamm Res. 2024 Sep 5;17:6075-6082. doi: 10.2147/JIR.S473655. eCollection 2024.
Inflammation plays a significant role in the proliferation, migration, and differentiation of lens epithelial cells after cataract surgery, clinically manifested as posterior capsule opacification (PCO). This condition is typically treated with neodymium: yttrium-aluminum-garnet (Nd:YAG) laser capsulotomy. Our objective is to evaluate the association between blood-derived inflammatory markers and the development of clinically significant PCO necessitating treatment with laser capsulotomy.
We conducted a retrospective review of charts for all patients who underwent Nd:YAG laser capsulotomy in our department between January 2021 and December 2022. The study included 70 patients who diagnosed with clinically significant PCO requiring treatment with Nd:YAG laser capsulotomy following cataract surgery, as well as 70 pseudophakic controls with no signs of PCO. Complete blood cell count parameters were obtained from medical records and the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) were calculated.
The mean age of the Nd:YAG laser capsulotomy and control group was 71.83±8.46 and 72.27±9.98 years, respectively. The preoperative NLR scores for the Nd:YAG laser capsulotomy group (mean rank = 34.43) were statistically significantly higher than those of the control group (mean rank = 25.41) (p = 0.044). However, after adjusting for preoperative measurements, no statistically significant differences were observed between the groups for the other parameters.
Preoperative NLR scores were higher in patients who developed clinically significant PCO requiring treatment with Nd:YAG laser capsulotomy. This finding suggests that patients with elevated systemic inflammation may be at an increased risk of developing PCO following cataract surgery. Further research is needed to evaluate the role of systemic inflammation in the pathogenesis of PCO.
炎症在白内障手术后晶状体上皮细胞的增殖、迁移和分化过程中起着重要作用，临床表现为后囊膜混浊（PCO）。这种情况通常采用钕：钇铝石榴石（Nd:YAG）激光囊膜切开术进行治疗。我们的目的是评估血液中炎症标志物与需要进行激光囊膜切开术治疗的具有临床意义的PCO发生之间的关联。
我们对2021年1月至2022年12月期间在我科接受Nd:YAG激光囊膜切开术的所有患者的病历进行了回顾性研究。该研究包括70例诊断为白内障手术后需要用Nd:YAG激光囊膜切开术治疗的具有临床意义的PCO患者，以及70例无PCO迹象的人工晶状体植入对照患者。从病历中获取全血细胞计数参数，并计算中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）和单核细胞与淋巴细胞比值（MLR）。
Nd:YAG激光囊膜切开术组和对照组的平均年龄分别为71.83±8.46岁和72.27±9.98岁。Nd:YAG激光囊膜切开术组的术前NLR评分（平均秩次 = 34.43）在统计学上显著高于对照组（平均秩次 = 25.41）（p = 0.044）。然而，在对术前测量值进行校正后，两组在其他参数方面未观察到统计学上的显著差异。
发生需要用Nd:YAG激光囊膜切开术治疗的具有临床意义的PCO的患者术前NLR评分较高。这一发现表明，全身炎症水平升高的患者在白内障手术后发生PCO的风险可能增加。需要进一步研究来评估全身炎症在PCO发病机制中的作用。
