Alibegović Armin
Institute of Forensic Medicine, Faculty of Medicine, University of Ljubljana, Korytkova 2, 1000, Ljubljana, Slovenia.
Forensic Sci Med Pathol. 2018 Dec;14(4):564-567. doi: 10.1007/s12024-018-0015-6. Epub 2018 Sep 3.
Hypogonadism in men results from the failure of the testes to produce physiological levels of testosterone and a normal number of spermatozoa due to a disruption of the hypothalamic-pituitary-testicular axis. An example of secondary hypogonadism as a result of anabolic steroid abuse is presented with the case report of a man who committed suicide after a history of aggressive behavior and physical abuse of his wife. The autopsy revealed shrunken testicles, with more than 30% of parenchymatous sclerosis, absent spermatogenesis, and very few Leydig cells detected only by immunohistochemistry. A low-specific immunochemical analysis revealed a very high level of total testosterone (serum 109.8 nmol/L; urine 81.2 nmol/L). A more accurate analysis confirmed an overdose of synthetic anabolic steroids. Doctors in different medical areas should be alerted to chronic abusers of synthetic anabolic steroids among the growing number of recreational athletes.
男性性腺功能减退是由于下丘脑 - 垂体 - 睾丸轴的破坏，导致睾丸无法产生生理水平的睾酮和正常数量的精子。本文通过一例因滥用合成代谢类固醇导致继发性性腺功能减退的病例报告进行阐述，该男子在出现攻击性行为和对妻子身体虐待的病史后自杀。尸检显示睾丸萎缩，实质硬化超过30%，无精子发生，仅通过免疫组织化学检测到极少数的睾丸间质细胞。低特异性免疫化学分析显示总睾酮水平极高（血清109.8 nmol/L；尿液81.2 nmol/L）。更精确的分析证实存在合成代谢类固醇过量。在越来越多的业余运动员中，不同医学领域的医生应警惕合成代谢类固醇的慢性滥用者。
