Bai Huimin, Shiota Tomoyuki, Yoshizaki Sayaka, Saito-Obata Mariko, Malbas Fedelino F, Lupisan Socorro P, Oshitani Hitoshi, Takeda Naokazu, Muramatsu Masamichi, Wakita Takaji, Ishii Koji, Li Tian-Cheng
Department of Basic Medicine and Forensic Medicine, Baotou Medical College, Baotou Inner Mongolia.
Department of Virology II, National Institute of Infectious Diseases.
Jpn J Infect Dis. 2019 Jan 23;72(1):53-55. doi: 10.7883/yoken.JJID.2018.148. Epub 2018 Aug 31.
Hepatitis A virus (HAV) is a common infectious etiology of acute hepatitis worldwide. The Philippines remains highly endemic for hepatitis A, but there is still a lack of information about HAV in the country. To evaluate the HAV contamination in environmental water in the Philippines, we conducted the detection and genetic analyses of HAV RNA in samples from river water. Twelve water samples were collected at 6 sampling sites of 3 rivers in Metro Manila, in both the dry and wet seasons in 2012 and 2013. The HAV RNA was detected in all the 6 samples collected in the dry season, and in one sample from the wet season. Phylogenetic analysis confirmed that the HAV strains detected in the river water included multiple sequences belonging to subgenotypes IA and IIIA. This indicates that at least 2 genotypes of the HAV strains are circulating in the environment in the Philippines, posing a risk of HAV infection to not only residents, but also tourists, especially in the dry season.
甲型肝炎病毒（HAV）是全球急性肝炎常见的感染病因。菲律宾仍是甲型肝炎的高流行地区，但该国仍缺乏有关HAV的信息。为评估菲律宾环境水体中的HAV污染情况，我们对河水样本进行了HAV RNA检测及基因分析。2012年和2013年的旱季和雨季，在马尼拉大都会3条河流的6个采样点采集了12份水样。旱季采集的所有6份样本以及雨季的1份样本中均检测到HAV RNA。系统发育分析证实，河水中检测到的HAV毒株包括多个属于IA和IIIA亚基因型的序列。这表明至少2种基因型的HAV毒株在菲律宾环境中传播，不仅对当地居民，而且对游客都构成了HAV感染风险，尤其是在旱季。
