Department of Dermatology, Shandong Provincial Hospital for Skin Disease, Shandong University, Jinan, China.
Acta Derm Venereol. 2019 Jan 1;99(1):84-88. doi: 10.2340/00015555-3027.
Genome-wide association studies have recently identified a number of non-major histocompatibility complex regions associated with psoriatic arthritis. However, data on Chinese patients with psoriatic arthritis and the differences between psoriatic arthritis and cutaneous psoriasis are limited. This study genotyped 12 single nucleotide polymorphisms in 379 patients with psoriatic arthritis, 376 with cutaneous psoriasis, and 760 healthy controls using Sequenom's Mass ARRAY system. The aim of the study was to expand the database for psoriatic arthritis and cutaneous psoriasis, and develop a genetic prediction system for the early diagnosis of psoriatic arthritis in the Chinese population. One variant in NFKBIA, rs12883343, had a significantly different association with psoriatic arthritis than with cutaneous psoriasis (p = 4.93×10-10, odds ratio 2.371). This suggests that there are differences in the pathogenesis of psoriatic arthritis and cutaneous psoriasis.
全基因组关联研究最近确定了许多与银屑病关节炎相关的非主要组织相容性复合体区域。然而，关于中国银屑病关节炎患者的数据以及银屑病关节炎与皮肤银屑病之间的差异有限。本研究使用 Sequenom 的 Mass ARRAY 系统对 379 例银屑病关节炎患者、376 例皮肤银屑病患者和 760 例健康对照者的 12 个单核苷酸多态性进行了基因分型。本研究的目的是扩展银屑病关节炎和皮肤银屑病的数据库，并为中国人群中银屑病关节炎的早期诊断开发遗传预测系统。NFKBIA 中的一个变体 rs12883343 与银屑病关节炎的关联明显不同于与皮肤银屑病的关联（p=4.93×10-10，优势比 2.371）。这表明银屑病关节炎和皮肤银屑病的发病机制存在差异。
