Drucker D, McLaughlin J
Crit Care Med. 1986 Sep;14(9):789-91. doi: 10.1097/00003246-198609000-00006.
To further characterize the adrenocortical response to acute illness, we measured basal and adrenocorticotropic hormone (ACTH)-stimulated 11-deoxycortisol, androstenedione, and dehydroepiandrosterone sulfate (DHEAS). Acutely ill patients had higher ACTH-stimulated 11-deoxycortisol and androstenedione, and decreased basal and ACTH-stimulated androstenedione/cortisol and DHEAS/cortisol ratios. Our data suggest that a shift away from androgen synthesis toward the glucocorticoid pathway occurs in acute illness.
为了进一步描述肾上腺皮质对急性疾病的反应，我们测量了基础状态下以及促肾上腺皮质激素（ACTH）刺激后的11-脱氧皮质醇、雄烯二酮和硫酸脱氢表雄酮（DHEAS）。急性病患者ACTH刺激后的11-脱氧皮质醇和雄烯二酮水平较高，基础状态下以及ACTH刺激后的雄烯二酮/皮质醇和DHEAS/皮质醇比值降低。我们的数据表明，急性疾病时发生了从雄激素合成向糖皮质激素途径的转变。
