Department of Bionanotechnology, Gachon University, San 65, Bokjeong-Dong, Sujeong-Gu, Seongnam-Si, Gyeonggi-Do 461-701, Republic of Korea.
Department of Bionanotechnology, Gachon University, San 65, Bokjeong-Dong, Sujeong-Gu, Seongnam-Si, Gyeonggi-Do 461-701, Republic of Korea.
Colloids Surf B Biointerfaces. 2018 Dec 1;172:315-322. doi: 10.1016/j.colsurfb.2018.08.057. Epub 2018 Aug 28.
Cancer is one of the most abundant causes of death in the world due to its characteristic features such as indefinite growth of cells, invasion of healthy tissues, and also metastasis. Conventional treatments of both chemotherapy and radiation have intense side effects and kills cancer cells along with normal healthy cells. Therefore, targeted drug delivery system has become the most suitable way to optimize all the side effects involved in conventional drug delivery systems. Among the various targeted drug delivery systems, nucleic acid-based nanoparticles are providing a constructive treatment option against cancer. The rapid advancement of nucleic acid-based nanomedicine will lead to an effective tumor targeted drug delivery in an optimal manner. Promising features such as potential targeted drug delivery, better biocompatibility, and self-programmability could make nucleic acids as an effective nanocarrier as well as an optimal tool in the treatment of cancer. This review presents the recent insights into the development of nucleic acid-based nanoparticles for tumor-targeted drug delivery and discussed their importance and limitations in successful drug delivery for effective anticancer therapy.
癌症是世界上最主要的死亡原因之一，其特征包括细胞的无限生长、健康组织的侵袭以及转移。化疗和放疗等传统疗法具有强烈的副作用，会杀死癌细胞和正常健康细胞。因此，靶向药物输送系统已成为优化传统药物输送系统中所有副作用的最适宜方法。在各种靶向药物输送系统中，基于核酸的纳米颗粒为癌症提供了一种有建设性的治疗选择。核酸纳米医学的快速发展将以最佳方式实现有效的肿瘤靶向药物输送。有前途的特性，如潜在的靶向药物输送、更好的生物相容性和自我编程性，可以使核酸成为有效的纳米载体以及癌症治疗的最佳工具。本文综述了核酸纳米颗粒在肿瘤靶向药物输送方面的最新研究进展，并讨论了其在成功药物输送中用于有效抗癌治疗的重要性和局限性。
