Department of Pharmacy, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, Personalized Drug Therapy Key Laboratory of Sichuan Province, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610000, People's Republic of China.
College of Pharmacy, Southwest Minzu University, Chengdu, 610000, People's Republic of China.
Int J Nanomedicine. 2022 Sep 19;17:4367-4381. doi: 10.2147/IJN.S385590. eCollection 2022.
Pancreatitis is an inflammatory reaction of pancreatic tissue digestion, edema, bleeding and even necrosis caused by activation of pancreatin due to various causes. In particular, patients with severe acute pancreatitis (SAP) often suffer from secondary infection, peritonitis and shock, and have a high mortality rate. Chronic pancreatitis (CP) can cause permanent damage to the pancreas. Due to the innate characteristics, structure and location of the pancreas, there is no effective treatment, only relief of symptoms. Especially, AP is an unpredictable and potentially fatal disease, and the timely diagnosis and treatment remains a major challenge. With the rapid development of nanomedicine technology, many potential tools can be used to address this problem. In this review, we have introduced the pathophysiological processes of pancreatitis to understanding its etiology and severity. Most importantly, the current progress in the diagnosis and treatment tools of pancreatitis based on nanomedicine is summarized and prospected.
胰腺炎是由于各种原因导致胰酶激活而引起的胰腺组织消化、水肿、出血甚至坏死的炎症反应。特别是重症急性胰腺炎（SAP）患者常继发感染、腹膜炎和休克，死亡率高。慢性胰腺炎（CP）可导致胰腺的永久性损伤。由于胰腺的先天特性、结构和位置，目前尚无有效的治疗方法，只能缓解症状。特别是 AP 是一种不可预测且潜在致命的疾病，及时诊断和治疗仍然是一个重大挑战。随着纳米医学技术的快速发展，许多潜在的工具可以用于解决这个问题。在这篇综述中，我们介绍了胰腺炎的病理生理过程，以了解其病因和严重程度。最重要的是，总结和展望了基于纳米医学的胰腺炎诊断和治疗工具的最新进展。
