Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.
Bioorg Chem. 2018 Dec;81:319-325. doi: 10.1016/j.bioorg.2018.08.027. Epub 2018 Aug 27.
In addition to CAF-603, 14-hydroxy CAF-603 (trichocarane B), 7-β-hydroxy CAF-603, and trichocarane A, eight new carotane sesquiterpenes, trichocarotins A-H, and one new cadinane sesquiterpene, trichocadinin A, were isolated from the culture of Trichoderma virens Y13-3, obtained from the surface of a marine red alga. Their structures and relative configurations were unambiguously assigned by interpretation of 1D/2D NMR and MS data, and their absolute configurations were established by X-ray diffraction or ECD spectra aided by quantum chemical calculations. These compounds represent two rarely occurring sesquiterpene types from filamentous fungi, and six of them feature potent inhibition against some marine plankton species.
除了 CAF-603、14-羟基 CAF-603（三齿烷 B）、7-β-羟基 CAF-603 和三齿烷 A 之外，从海洋红藻表面分离到的绿色木霉 Y13-3 的培养物中还分离到了八种新的胡萝卜烷倍半萜，即三齿烷 A-H，以及一种新的卡达烯倍半萜，即三齿卡达宁 A。通过解析 1D/2D NMR 和 MS 数据，明确了它们的结构和相对构型，并通过 X 射线衍射或 ECD 光谱结合量子化学计算确定了它们的绝对构型。这些化合物代表了两种来自丝状真菌的罕见倍半萜类型，其中六种化合物对一些海洋浮游生物具有很强的抑制作用。
