三齿菌素 B-G：来源于药用植物内生真菌 QA-8 的抗菌卡丹烷倍半萜
Trichocadinins B-G: Antimicrobial Cadinane Sesquiterpenes from QA-8, an Endophytic Fungus Obtained from the Medicinal Plant .
机构信息
Key Laboratory of Experimental Marine Biology, Institute of Oceanology , Chinese Academy of Sciences, and Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology , Nanhai Road 7 , Qingdao 266071 , People's Republic of China.
College of Chemistry and Chemical Engineering , Hubei Normal University , Cihu Road 11 , Huangshi 435002 , People's Republic of China.
出版信息
J Nat Prod. 2019 Sep 27;82(9):2470-2476. doi: 10.1021/acs.jnatprod.9b00139. Epub 2019 Aug 16.
Trichocadinins B-G (-), six new cadinane-type sesquiterpene derivatives, each with C-14 carboxyl functionality, were isolated from the culture extract of QA-8, an endophytic fungus obtained from the fresh inner tissue of the medicinal plant . Their structures were elucidated by interpretation of the NMR spectroscopic and mass spectrometric data. The structures and absolute configurations of compounds and were confirmed by X-ray crystallographic analysis. Compounds - showed antibacterial and antifungal activity.
三齿菌素 B-G(-)，六个新的卡丹烷型倍半萜衍生物，每个都具有 C-14 羧基功能，是从 QA-8 的培养提取物中分离得到的，QA-8 是一种内生真菌，从药用植物的新鲜内部组织中获得。它们的结构是通过对 NMR 光谱和质谱数据的解释来阐明的。化合物和的结构和绝对构型通过 X 射线晶体学分析得到证实。化合物-表现出抗菌和抗真菌活性。
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