Maurer R, Reubi J C
Eur J Pharmacol. 1986 Jun 17;125(2):241-7. doi: 10.1016/0014-2999(86)90033-6.
Receptors sites for angiotensin II and atrial natriuretic factor were concentrated in the zone glomerulosa of the adrenal cortex in the rat, mouse, hamster, rhesus monkey, guinea-pig and the cow. Angiotensin Ii receptor sites were also accumulated in adrenal medullary tissue of the rat, mouse and the hamster. With exception of the cow the zonae fasciculata and reticulata of the adrenal cortex were not labelled with the angiotensin II ligand, but showed a moderate density of atrial natriuretic factor receptor sites in all species except the rhesus monkey. In comparison, somatostatin receptors were even more heterogeneously distributed in all species mentioned above. In the rat, the increased growth of zona glomerulosa cells found after three weeks of sodium deprivation was accompanied by a similar increase in number of receptor sites for angiotensin II, atrial natriuretic factor and somatostatin. This shows that all three peptide receptors are regulated simultaneously by a single metabolic disturbance, suggesting that they might be localized on the same cell type in the adrenal cortex.
血管紧张素II和心房利钠因子的受体位点集中在大鼠、小鼠、仓鼠、恒河猴、豚鼠和牛的肾上腺皮质球状带。血管紧张素II受体位点也聚集在大鼠、小鼠和仓鼠的肾上腺髓质组织中。除牛外，肾上腺皮质束状带和网状带未被血管紧张素II配体标记，但在除恒河猴外的所有物种中显示出中等密度的心房利钠因子受体位点。相比之下，生长抑素受体在上述所有物种中的分布更加不均匀。在大鼠中，缺钠三周后发现的球状带细胞生长增加伴随着血管紧张素II、心房利钠因子和生长抑素受体位点数量的类似增加。这表明所有三种肽受体都受到单一代谢紊乱的同时调节，表明它们可能位于肾上腺皮质的同一细胞类型上。
