Department of Chemistry , University of Missouri-Columbia , Columbia , Missouri 65211 , United States.
Org Lett. 2018 Sep 21;20(18):5723-5726. doi: 10.1021/acs.orglett.8b02440. Epub 2018 Sep 4.
Treatment of allenyl sulfonamides with catalytic amounts of silver fluoride in acetonitrile at reflux afforded the corresponding 3-sulfonyl-3-pyrrolines in excellent yields by intramolecular hydroamination via a 5- endo-trig cyclization. The starting allenyl sulfonamides were prepared by lithiation of allenic sulfones and trapping with various N-sulfonylimines.
在回流的乙腈中，用催化量的氟化银处理烯丙基磺酰胺，通过 5-endo-trig 环化的分子内氢胺化反应，以优异的收率得到相应的 3-磺酰基-3-吡咯啉。起始的烯丙基磺酰胺是通过烯丙基砜的锂化和与各种 N-磺酰亚胺的捕获来制备的。
