Section of Gastroenterology, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts.
Department of Biostatistics, Boston University, Boston, Massachusetts.
Liver Int. 2019 Apr;39(4):740-747. doi: 10.1111/liv.13956. Epub 2018 Sep 25.
BACKGROUND & AIMS: Little is known regarding the risk of hepatic steatosis (HS) among adult children of affected parents. We examined the association between parental and offspring HS in the multigenerational Framingham Heart Study, which characterized HS using computed tomography.
We performed multivariable logistic regression models adjusted for age, sex, alcohol use, and body mass index to generate the odds of HS according to parental HS. We determined the proportion of participants with HS according to parental HS and the presence or absence of hypertension, diabetes, or obesity (BMI ≥30 kg/m ). After excluding heavy alcohol use (n = 126) and missing covariates (n = 1), 785 offspring with at least one parent were included.
Approximately 23% (183/785) had at least one parent with HS and 1.1% had two affected parents (9/785). In adjusted models, participants with at least one parent with HS had a nearly two-fold increased odds of HS compared to participants without a parental history of HS (OR 1.86, 95% confidence interval 1.15-3.03). Among participants without hypertension, diabetes, or obesity, a higher proportion had HS if they had a parental history of HS compared to those without (16.1% vs 5.2%, P < 0.001). However, for participants with cardiometabolic risk factors, we did not observe a difference in HS among those with and without parental HS (30.3% vs 28.5%, P = 0.78).
Individuals with a parental history of HS are at increased risk for HS. Specifically, a parental history of HS may be an important factor among those that are otherwise metabolically healthy.
人们对父母患病子女患肝脂肪变性（HS）的风险知之甚少。我们通过使用计算机断层扫描（CT）对 HS 进行特征描述，在 Framingham 心脏研究的多代人群中研究了父母与子女 HS 之间的关联。
我们采用多变量逻辑回归模型，根据父母的 HS 情况调整年龄、性别、饮酒和体重指数（BMI），以生成 HS 的比值比（OR）。我们根据父母的 HS 情况和是否存在高血压、糖尿病或肥胖症（BMI≥30kg/m ）确定 HS 患者的比例。排除大量饮酒（n=126）和缺失的协变量（n=1）后，纳入 785 名至少有一名父母的子女。
大约 23%（183/785）的子女至少有一位父母患有 HS，1.1%的子女有两位患病父母（9/785）。在调整后的模型中，与没有父母 HS 史的参与者相比，至少有一位父母患有 HS 的参与者发生 HS 的几率增加近两倍（OR 1.86，95%置信区间 1.15-3.03）。在没有高血压、糖尿病或肥胖症的参与者中，与没有父母 HS 史的参与者相比，有父母 HS 史的参与者 HS 发生率更高（16.1%比 5.2%，P<0.001）。然而，对于存在心血管代谢危险因素的参与者，我们没有观察到父母 HS 史对 HS 发生率的影响存在差异（30.3%比 28.5%，P=0.78）。
有父母 HS 史的个体发生 HS 的风险增加。具体来说，父母 HS 史可能是那些代谢健康的个体中一个重要的因素。
