Department of Dermatology, Regensburg University Medical Center, Regensburg, Germany.
J Dtsch Dermatol Ges. 2018 Sep;16(9):1120-1129. doi: 10.1111/ddg.13646.
The efficacy of phototherapy is based on the interaction between ultraviolet (UV) radiation and the skin. The photobiological effects thus achieved depend on the wavelengths used. Targeted use of UVA and UVB, where indicated in combination with a photosensitizer such as psoralen, provides the dermatologist with a broad armamentarium for the treatment of a multitude of skin diseases. The spectrum of indications ranges from superficial dermatitis, psoriasis, and malignancies, such as cutaneous T-cell lymphoma, to deep sclerosing conditions such as morphea. The objective of the present review is to highlight the photobiological effects of the various types of UV radiation as well as the resultant clinical indications for phototherapy.
光疗的疗效基于紫外线 (UV) 辐射与皮肤的相互作用。因此，实现的光生物学效应取决于所使用的波长。有针对性地使用 UVA 和 UVB，并在必要时结合补骨脂素等光敏剂使用，为皮肤科医生提供了治疗多种皮肤疾病的广泛手段。适应症的范围从浅表性皮炎、银屑病和恶性肿瘤（如皮肤 T 细胞淋巴瘤）到深部硬化性疾病（如硬斑病）。本综述的目的是强调各种类型的 UV 辐射的光生物学效应以及由此产生的光疗临床适应症。
