近期关于胰腺癌中天冬氨酸 β-羟化酶 (ASPH) 的研究进展：简要更新。
Recent advances in research on aspartate β-hydroxylase (ASPH) in pancreatic cancer: A brief update.
机构信息
Department of Pancreatic and Biliary Surgery, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.
出版信息
Bosn J Basic Med Sci. 2018 Nov 5;18(4):297-304. doi: 10.17305/bjbms.2018.3539.
Abstract
Pancreatic cancer (PC) is a highly aggressive tumor, often difficult to diagnose and treat. Aspartate β-hydroxylase (ASPH) is a type II transmembrane protein and the member of α-ketoglutarate-dependent dioxygenase family, found to be overexpressed in different cancer types, including PC. ASPH appears to be involved in the regulation of proliferation, invasion and metastasis of PC cells through multiple signaling pathways, suggesting its role as a tumor biomarker and therapeutic target. In this review, we briefly summarize the possible mechanisms of action of ASPH in PC and recent progress in the therapeutic approaches targeting ASPH.
摘要
胰腺癌（PC）是一种侵袭性很强的肿瘤，通常难以诊断和治疗。天冬氨酸 β-羟化酶（ASPH）是一种 II 型跨膜蛋白，属于 α-酮戊二酸依赖性双加氧酶家族成员，在不同类型的癌症中均有过表达，包括 PC。ASPH 似乎通过多种信号通路参与调节 PC 细胞的增殖、侵袭和转移，提示其作为肿瘤生物标志物和治疗靶点的作用。在这篇综述中，我们简要总结了 ASPH 在 PC 中的可能作用机制以及针对 ASPH 的治疗方法的最新进展。
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