Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia; Laboratory of Preclinical Bioscreening, Granov Russian Research Center of Radiology and Surgical Technologies, Ministry of Healthcare of Russian Federation, Pesochny, Russia.
Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil; The International Zebrafish Neuroscience Research Consortium, Slidell, LA, USA.
Brain Res Bull. 2018 Sep;142:344-351. doi: 10.1016/j.brainresbull.2018.08.022. Epub 2018 Sep 1.
Epigenetic regulation has become a key focus of neuroscience and biopsychiatry, implicating DNA methylation, histone modification and other epigenetic mechanisms in various CNS disorders. Animal (experimental) models are a useful tool for epigenetic studies. Although most such research has been performed in rodents, the zebrafish (Danio rerio) is rapidly emerging as a new promising model organism in neuroscience. These fish are particularly suitable for genetic and epigenetic studies due to their fully sequenced genome, easiness of genetic analyses and high physiological and genetic homology with humans. Here, we discuss mounting evidence of epigenetic regulation of CNS functions in zebrafish, and outline future directions of translational research in this field.
表观遗传调控已成为神经科学和生物精神病学的一个重要焦点，提示 DNA 甲基化、组蛋白修饰和其他表观遗传机制参与了各种中枢神经系统疾病。动物（实验）模型是表观遗传学研究的有用工具。尽管此类研究大多在啮齿动物中进行，但斑马鱼（Danio rerio）作为一种新的神经科学有前途的模式生物迅速崛起。这些鱼类由于其全基因组测序、易于进行基因分析以及与人类具有高度生理和遗传同源性，特别适合进行遗传和表观遗传研究。在这里，我们讨论了在斑马鱼中中枢神经系统功能的表观遗传调控的不断增加的证据，并概述了该领域转化研究的未来方向。
