de Abreu Murilo S, Demin Konstantin A, Giacomini Ana C V V, Amstislavskaya Tamara G, Strekalova Tatyana, Maslov Gleb O, Kositsin Yury, Petersen Elena V, Kalueff Allan V
Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil.
Laboratory of Cell and Molecular Biology and Neurobiology, Moscow Institute of Physics and Technology, Moscow, Russia.
Neurobiol Stress. 2021 Sep 29;15:100405. doi: 10.1016/j.ynstr.2021.100405. eCollection 2021 Nov.
Stress response is essential for the organism to quickly restore physiological homeostasis disturbed by various environmental insults. In addition to well-established physiological cascades, stress also evokes various brain and behavioral responses. Aquatic animal models, including the zebrafish (), have been extensively used to probe pathobiological mechanisms of stress and stress-related brain disorders. Here, we critically discuss the use of zebrafish models for studying mechanisms of stress and modeling its disorders experimentally, with a particular cross-taxon focus on the potential evolution of stress responses from zebrafish to rodents and humans, as well as its translational implications.
应激反应对于生物体迅速恢复因各种环境损伤而被扰乱的生理稳态至关重要。除了已确立的生理级联反应外，应激还会引发各种大脑和行为反应。包括斑马鱼在内的水生动物模型已被广泛用于探究应激及与应激相关的脑部疾病的病理生物学机制。在此，我们批判性地讨论斑马鱼模型在研究应激机制及通过实验模拟其疾病方面的应用，特别从跨分类群角度关注应激反应从斑马鱼到啮齿动物和人类的潜在演化，以及其转化意义。
