Tan Yi-Ling, Singh Kuldip, Tan Kok Hian, Gosavi Arundhati, Koh Daniel, Abbas Dina, Winikoff Beverly
Gynuity Health Projects, New York, NY, USA.
Women's Centre, National University Hospital, Singapore.
Eur J Obstet Gynecol Reprod Biol. 2018 Oct;229:144-147. doi: 10.1016/j.ejogrb.2018.08.014. Epub 2018 Aug 28.
The aim of the study was to examine the acceptability and feasibility of using a combined regimen of 200 mg mifepristone and 800 μg buccal misoprostol in an outpatient abortion service in Singapore, where mifepristone is not currently registered.
The pilot prospective study enrolled 130 women who sought termination of pregnancies up to 70 days gestation at two public hospitals in Singapore. Women received 200 mg mifepristone to take at the clinic or at home, followed 24 h later by 800 μg buccal misoprostol administered at home. A follow-up visit was scheduled seven to ten days after mifepristone to confirm the outcome of the abortion. The primary outcome was rate of successful abortion and secondary outcomes were women's preference for location of mifepristone administration and satisfaction with the method.
The large majority of women (96.8%) had successful abortions without recourse to surgical intervention. Most women (88.2%) chose to take mifepristone at the clinic. Most women reported the side effects as acceptable (68.3%) or neutral (26.0%). Almost all women (94.4%) were very satisfied or satisfied with the method.
Outpatient medical abortion with mifepristone and misoprostol up to 70 days gestation is acceptable and feasible and has the potential to expand available options in Singapore.
本研究旨在探讨在新加坡米非司酮尚未注册的情况下，在门诊堕胎服务中使用200毫克米非司酮和800微克口腔用米索前列醇联合方案的可接受性和可行性。
这项前瞻性试点研究招募了130名在新加坡两家公立医院寻求终止妊娠70天内妊娠的女性。女性接受200毫克米非司酮，可在诊所或家中服用，24小时后在家中服用800微克口腔用米索前列醇。在服用米非司酮后7至10天安排随访，以确认堕胎结果。主要结局是堕胎成功率，次要结局是女性对米非司酮给药地点的偏好以及对该方法的满意度。
绝大多数女性（96.8%）在无需手术干预的情况下成功堕胎。大多数女性（88.2%）选择在诊所服用米非司酮。大多数女性报告副作用可接受（68.3%）或无明显影响（26.0%）。几乎所有女性（94.4%）对该方法非常满意或满意。
妊娠70天内使用米非司酮和米索前列醇进行门诊药物流产是可接受且可行的，并且有可能在新加坡扩大可用选择。
