Bural Canan, Güven Melahat Çelik, Kayacıoğlu Büşra, Ak Gülsüm, Bayraktar Gülsen, Bilhan Hakan
Int J Prosthodont. 2018 Sep/Oct;31(5):481-484. doi: 10.11607/ijp.5803.
To investigate the effects of over-the-counter products on the healing of denture-induced ulcerations and patients' self-reported pain.
A total of 140 patients with acute denture-induced ulcerations were randomized into seven treatment groups: denture grinding (control); topical application of corn oil gel (placebo); triester glycerol oxide gel; D-panthenol gel; D-panthenol mouthwash; L-arginine mouthwash; and hyaluronic acid gel. Healing and self-reported pain were assessed after 1, 3, and 7 days of treatment.
The percentage of healed lesions in the mandible and maxilla after 7 days was 67% and 65%, respectively. The only significance in healing was for mandibular lesions at 3 days after application of L-arginine mouthwash; at this period, the healing rate was significantly higher than d-panthenol gel, d-panthenol mouthwash, and hyaluronic acid gel (P < .05).
Denture grinding as the current protocol for acute denture-induced ulcerations should remain as the default.
研究非处方产品对义齿性溃疡愈合及患者自我报告疼痛的影响。
总共140例急性义齿性溃疡患者被随机分为7个治疗组：义齿打磨（对照组）；局部应用玉米油凝胶（安慰剂）；三酯甘油氧化物凝胶；D-泛醇凝胶；D-泛醇漱口水；L-精氨酸漱口水；透明质酸凝胶。在治疗1、3和7天后评估愈合情况及患者自我报告的疼痛。
7天后下颌骨和上颌骨愈合病变的百分比分别为67%和65%。愈合方面唯一有显著差异的是在应用L-精氨酸漱口水3天后的下颌病变；在此期间，愈合率显著高于D-泛醇凝胶、D-泛醇漱口水和透明质酸凝胶（P <.05）。
作为目前急性义齿性溃疡治疗方案的义齿打磨应作为默认方法保留。
