Lee S S, Braillon A, Girod C, Geoffroy P, Lebrec D
J Hepatol. 1986;3(1):38-41. doi: 10.1016/s0168-8278(86)80143-x.
The haemodynamic effect of sudden termination of propranolol therapy was studied in sham-operated and portal hypertensive rats. All animals were injected with propranolol (20 mg/kg/day) or saline i.p. for 10 days, then had an isoproterenol infusion test performed 48 h or 72 h after cessation of injections. The dose of isoproterenol required to increase the heart rate by 50 beats/min (CD50), was significantly lower in both sham-operated and portal hypertensive rats at 48 h after propranolol withdrawal. Maximum chronotropic response (Rmax), was significantly higher only in portal hypertensive rats at 48 h after propranolol withdrawal. These results show the existence of a transient beta-adrenergic hypersensitivity state following propranolol withdrawal in normal and portal hypertensive rats.
在假手术大鼠和门静脉高压大鼠中研究了普萘洛尔治疗突然终止后的血流动力学效应。所有动物腹腔注射普萘洛尔（20mg/kg/天）或生理盐水，持续10天，然后在注射停止后48小时或72小时进行异丙肾上腺素输注试验。在普萘洛尔撤药后48小时，假手术大鼠和门静脉高压大鼠中使心率增加50次/分钟所需的异丙肾上腺素剂量（CD50）均显著降低。最大变时反应（Rmax）仅在普萘洛尔撤药后48小时的门静脉高压大鼠中显著更高。这些结果表明，在正常大鼠和门静脉高压大鼠中，普萘洛尔撤药后存在短暂的β-肾上腺素能超敏状态。
