Mu Yuyuan, Wang Zhichao, Zhou Jiexin, Tan Chenxi, Wang Hongjiao
Dept. of Neurology, Second Affiliated Hospital of Qiqihar Medical College, Qiqihar Heilongjiang, 161000, P.R. China.
Dept. of Academic Research, Qiqihar Medical University, Qiqihar, 161000, P.R. China.
Iran J Public Health. 2018 Jul;47(7):988-993.
We aimed to investigate the correlations of the inflammatory response factors, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), high-sensitivity C-reactive protein (CRP), with patients with post-stroke depression (PSD), so as to provide a basis for the treatment and prevention of PSD for patients.
The clinical laboratory data of 60 patients with PSD in The Second Affiliated Hospital of Qiqihar Medical University, Qiqihar, China from July 2016 to July 2017 and those of another 60 stroke patients without PSD admitted in the same period were analyzed retrospectively. The expression levels of inflammatory response factors in the two groups of patients and in PSD patients with different levels of depression were compared and analyzed via statistical methods. Multiple Logistic regression analysis was used to determine whether inflammatory response factors were independent risk factors for PSD patients.
The expression levels of IL-6, TNF-α and CRP in patients with PSD were significantly increased compared with those in patients without PSD, and the differences were statistically significant (=6.429, =6.355, =5.792, <0.001). The levels of IL-6, TNF-α and CRP had statistically significant differences between any two groups of mild, moderate and severe PSD patients (<0.05). Results of multiple Logistic regression analysis revealed that the odds ratio (OR) values of inflammatory factors (IL-6, TNF-α and CRP) were 1.160, 1.099 and 1.248, respectively, and the corresponding values were 0.020, 0.039 and 0.007 in patients of observation group, indicating the above three inflammatory response factors were independent risk factors for PSD.
The clinic control on the expression levels of inflammatory response factors (IL-6, TNF-α and CRP) are extremely important for the treatment and prevention of PSD.
我们旨在研究炎症反应因子白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、高敏C反应蛋白（CRP）与中风后抑郁（PSD）患者之间的相关性，以便为PSD患者的治疗和预防提供依据。
回顾性分析2016年7月至2017年7月在中国齐齐哈尔齐齐哈尔医学院第二附属医院收治的60例PSD患者以及同期收治的另外60例无PSD的中风患者的临床实验室数据。通过统计学方法比较并分析两组患者以及不同抑郁程度的PSD患者中炎症反应因子的表达水平。采用多因素Logistic回归分析确定炎症反应因子是否为PSD患者的独立危险因素。
与无PSD的患者相比，PSD患者中IL-6、TNF-α和CRP的表达水平显著升高，差异具有统计学意义（=6.429，=6.355，=5.792，<0.001）。轻度、中度和重度PSD患者的任意两组之间，IL-6、TNF-α和CRP水平均有统计学差异（<0.05）。多因素Logistic回归分析结果显示，观察组患者炎症因子（IL-6、TNF-α和CRP）比值比（OR）值分别为1.160、1.099和1.248，相应值分别为0.020、0.039和0.007，表明上述三种炎症反应因子是PSD的独立危险因素。
临床控制炎症反应因子（IL-6、TNF-α和CRP）的表达水平对PSD的治疗和预防极为重要。
