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[老年期早发性物质使用障碍和成瘾性疾病]

[Early onset substance abuse disorders and addictive diseases in old age].

作者信息

Wolter Dirk K

机构信息

Abteilung Gerontopsychiatrie und Psychotherapie, LVR-Klinik Bonn, Akademisches Lehrkrankenhaus, Universität Bonn, Kaiser-Karl-Ring 20, 53111, Bonn, Deutschland.

出版信息

Z Gerontol Geriatr. 2018 Nov;51(7):758-769. doi: 10.1007/s00391-018-1440-6. Epub 2018 Sep 4.

DOI:10.1007/s00391-018-1440-6
PMID:30182256
Abstract

During the past 20 years substance-related and addictive disorders in old age have markedly increased and this increase is going to continue. It is quite common to make a distinction between early onset (EO) and late onset (LO) of these disorders. EO-addicts are in a more disadvantageous position due to constitutional and psychosocial burdens and the cumulating harmful medical, mental and social consequences of addiction place them at a further disadvantage during the course of the disorder. In old age they are at a disadvantage compared to others of the same age with LO addiction problems because of more and more severe chronic medical conditions, psychiatric comorbidity, less personal and social resources, dysfunctional coping style, and social problems. They present with lower treatment adherence and the treatment is difficult due to the combination of typical addictive behavior, psychiatric comorbidity, somatic diseases and in many cases also cognitive impairment. Treatment goals must be mostly individually defined and abstinence is rarely a realistic goal. Even the treatment has to be carried out mostly individually and often unconventionally. This article gives a review of the characteristic features of the course, presentation and adverse consequences of addictive disorders in EO addicts who have reached old age. The article covers alcohol, prescription drugs, illicit drugs and smoking as well as behavioral addictions.

摘要

在过去20年中,老年期物质相关及成瘾性障碍显著增加,且这种增长还将持续。通常会对这些障碍的早发型(EO)和晚发型(LO)进行区分。早发型成瘾者由于体质和心理社会负担而处于更为不利的境地,成瘾累积产生的有害医学、心理和社会后果使他们在疾病过程中进一步处于劣势。在老年期,与患有晚发型成瘾问题的同龄人相比,他们处于劣势,原因在于存在越来越严重的慢性疾病、精神疾病共病、个人和社会资源较少、应对方式功能失调以及社会问题。他们的治疗依从性较低,而且由于典型的成瘾行为、精神疾病共病、躯体疾病以及在许多情况下还存在认知障碍,治疗难度很大。治疗目标大多必须个体化确定,戒断很少是一个现实的目标。甚至治疗大多也必须个体化进行,而且往往是非传统的。本文综述了步入老年的早发型成瘾者成瘾性障碍的病程、表现及不良后果的特征。文章涵盖了酒精、处方药、非法药物、吸烟以及行为成瘾。

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Contribution of alcohol use disorders to the burden of dementia in France 2008-13: a nationwide retrospective cohort study.2008-2013 年法国因酒精使用障碍导致的痴呆负担:一项全国性回顾性队列研究。
Lancet Public Health. 2018 Mar;3(3):e124-e132. doi: 10.1016/S2468-2667(18)30022-7. Epub 2018 Feb 21.
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Benzodiazepine use and cognitive decline in the elderly.老年人使用苯二氮䓬类药物与认知功能衰退
Am J Health Syst Pharm. 2018 Jan 1;75(1):e6-e12. doi: 10.2146/ajhp160381.
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The Residual Medium and Long-term Cognitive Effects of Benzodiazepine Use: An Updated Meta-analysis.
苯二氮䓬类药物使用的残留中长期认知效应:一项更新的荟萃分析。
Arch Clin Neuropsychol. 2018 Nov 1;33(7):901-911. doi: 10.1093/arclin/acx120.
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Relationship between concomitant benzodiazepine-opioid use and adverse outcomes among US veterans.美国退伍军人中苯二氮䓬类药物-阿片类药物同时使用与不良结局的关系。
Pain. 2018 Mar;159(3):451-459. doi: 10.1097/j.pain.0000000000001111.
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Treatment for opioid use and outcomes in older adults: a systematic literature review.老年人阿片类药物使用的治疗方法和结局:系统文献回顾。
Drug Alcohol Depend. 2018 Jan 1;182:48-57. doi: 10.1016/j.drugalcdep.2017.10.007. Epub 2017 Nov 7.
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J Am Med Dir Assoc. 2018 Mar;19(3):240-247. doi: 10.1016/j.jamda.2017.09.013. Epub 2017 Nov 1.
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Prevalence of 12-Month Alcohol Use, High-Risk Drinking, and DSM-IV Alcohol Use Disorder in the United States, 2001-2002 to 2012-2013: Results From the National Epidemiologic Survey on Alcohol and Related Conditions.2001 - 2002年至2012 - 2013年美国12个月酒精使用、高危饮酒及《精神疾病诊断与统计手册》第四版酒精使用障碍的患病率:酒精及相关状况全国流行病学调查结果
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