Goldman School of Medicine, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Siaal Research Center for Primary Care, Division of Health in the Community, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
J Am Geriatr Soc. 2018 Sep;66(9):1684-1691. doi: 10.1111/jgs.15461. Epub 2018 Sep 5.
To compare the prevalence of cardiovascular diseases and risk factors in Holocaust survivors with that of Jewish immigrants from Europe and America.
Population-based, cross-sectional study.
Clalit, a large Israeli healthcare provider.
Holocaust survivors (n=83,971) and a comparison group of Jewish individuals born in North or South America or European countries not under Nazi occupation or who immigrated to Israel before 1939 (n=16,058) (mean age 84±7, 61% female) MEASUREMENTS: Univariate and multivariable logistic regression analyses of cardiovascular diseases and risk factors. Matching the comparison group to Holocaust Survivors on propensity scores for exposure.
The prevalence of ischemic heart disease (38.7% vs 31.3%), congestive heart failure (10.9% vs 9.1%), past stroke (15.7% vs 13.4%), and peripheral vascular disease (9.5% vs 7.9%) was higher in Holocaust survivors (p<.001 for all comparisons). Similar results were found for cardiovascular risk factors (diabetes mellitus (14.4% vs 13.6%), hypertension (89.3% vs 86.4%), dyslipidemia (75.9% vs 74.0%) (p<.001 for all comparisons). In multivariable analysis, matched on propensity scores and controlled for confounders, odds ratios for men and women were higher for diabetes (1.23, 1.55), dyslipidemia (1.53, 1.51), hypertension (1.56 , 1.94), stroke (1.18, 1.17), and ischemic heart disease (1.18, 1,40), but not congestive heart failure (0.95, 1.02). A Positive association was noted for peripheral vascular disease in males (1.20) but not females (0.96).
Prevalence of cardiovascular diseases and risk factors was higher in Holocaust survivors. These associations were stronger in women in most cases.
比较大屠杀幸存者与来自欧美地区的犹太移民在心血管疾病及相关风险因素方面的患病率。
基于人群的横断面研究。
Clalit，一家大型以色列医疗保健服务机构。
大屠杀幸存者（n=83971）和一个对照组，由非纳粹占领区出生于北美或南美或欧洲国家或于 1939 年前移民至以色列的犹太个体组成（n=16058）（平均年龄 84±7 岁，61%为女性）。
采用单变量和多变量逻辑回归分析心血管疾病及相关风险因素。采用倾向评分匹配对照人群与大屠杀幸存者。
与对照组相比，大屠杀幸存者缺血性心脏病（38.7% vs 31.3%）、充血性心力衰竭（10.9% vs 9.1%）、既往卒中（15.7% vs 13.4%）和外周血管疾病（9.5% vs 7.9%）的患病率更高（所有比较均 p<.001）。类似的结果也见于心血管风险因素（糖尿病（14.4% vs 13.6%）、高血压（89.3% vs 86.4%）、血脂异常（75.9% vs 74.0%）（所有比较均 p<.001）。在多变量分析中，经倾向评分匹配并控制混杂因素后，校正性别因素，男性和女性的糖尿病（1.23，1.55）、血脂异常（1.53，1.51）、高血压（1.56，1.94）、卒中和缺血性心脏病（1.18，1.40）的比值比更高，但充血性心力衰竭（0.95，1.02）除外。男性外周血管疾病呈正相关（1.20），而女性则无此相关性（0.96）。
大屠杀幸存者心血管疾病及相关风险因素的患病率更高。在大多数情况下，女性的这些关联更强。
