慢性多发性肌炎：肌肉中存在柯萨奇病毒A9抗原。
Chronic polymyositis: presence of coxsackievirus A9 antigen in muscle.
作者信息
Kuroda Y, Neshige R, Oda K, Shibasaki H
出版信息
Jpn J Med. 1986 May;25(2):191-4. doi: 10.2169/internalmedicine1962.25.191.
We report a case of chronic recurrent polymyositis associated with increasing antibody titers of coxsackievirus A9 in serum during clinical exacerbations. Muscle biopsy specimens showed pathologic changes consistent with chronic myositis, including perivascular mononuclear cell infiltration and hyalinization of muscle fibers with cytoplasmic vacuolations. The specific fluorescence was observed in the muscle fibers stained with antiserum for coxsackievirus A9. These findings indicate that this viral subtype as the etiologic agent in this case and virus plays a pathogenic role in some cases of chronic polymyositis.
我们报告一例慢性复发性多发性肌炎病例，在临床病情加重期间，血清中柯萨奇病毒A9抗体滴度升高。肌肉活检标本显示出与慢性肌炎一致的病理变化，包括血管周围单核细胞浸润以及伴有细胞质空泡形成的肌纤维玻璃样变。在用柯萨奇病毒A9抗血清染色的肌纤维中观察到特异性荧光。这些发现表明该病毒亚型为此病例的病原体，且病毒在某些慢性多发性肌炎病例中起致病作用。
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