Strongwater S L, Dorovini-Zis K, Ball R D, Schnitzer T J
Arthritis Rheum. 1984 Apr;27(4):433-42. doi: 10.1002/art.1780270411.
A murine model of polymyositis induced by coxsackievirus B1, Tucson strain (CVBT) is described. Intraperitoneal CVBT inoculation of CD 1 Swiss mice less than 48 hours old resulted in proximal hindquarter weakness that was first apparent 7 days after viral challenge and persisted for more than 10 weeks. Electromyographic and histologic evidence of a continuing myositis was present during this entire period of time. However, virus was not detectable later than 2 weeks post infection, despite clinical progression of disease. The finding of electromyographic and histologic abnormalities in CVBT-infected mice, long after virus had cleared and neutralizing antibody production evoked, suggests that persistent myositis may be immunologically mediated, triggered by the initial acute viral infection.
本文描述了由柯萨奇病毒B1图森株（CVBT）诱导的小鼠多发性肌炎模型。对小于48小时龄的CD1瑞士小鼠进行腹腔内CVBT接种，会导致后肢近端无力，在病毒攻击后7天首次出现，并持续超过10周。在这段时间内，存在持续性肌炎的肌电图和组织学证据。然而，尽管疾病有临床进展，但在感染后2周后就检测不到病毒了。在病毒清除且诱生中和抗体产生很久之后，在CVBT感染的小鼠中发现肌电图和组织学异常，这表明持续性肌炎可能是由最初的急性病毒感染触发的免疫介导反应。
