Kirev T T, Toshkov I A, Mladenov Z M
J Natl Cancer Inst. 1986 Sep;77(3):713-20. doi: 10.1093/jnci/77.3.713.
The morphologic lesions in the pancreas of 350 guinea fowls infected with avian osteopetrosis virus strain Pts-56 were studied. Focal unspecific changes in the acinar tissue, including reduction of zymogen content, diminution of cytoplasm, and dilatation of acinar lumens accompanied with substitution of the affected acini by tubular structures lined with centroacinar-like cells, developed 2 months from post infection (p.i.) in about 30% of the birds. Adenomatous growths of ductules with mucin-producing or mucin-nonproducing epithelium were observed independently or parallelly to these changes after 3 months p.i. Pancreatic carcinomas arose as early as 4 months p.i. The number and size of the neoplastic foci increased with time, and after the 6th month neoplastic foci were established in almost all infected guinea fowls. Neoplastic proliferations of type A and D endocrine cells were identified in the carcinoma foci of separate cases. Other associated neoplasms were bone tumors and papillomatous growths of the duodenal mucosa.
对350只感染禽骨质石化病毒株Pts - 56的珍珠鸡胰腺的形态学病变进行了研究。感染后2个月左右，约30%的禽类腺泡组织出现局灶性非特异性变化，包括酶原含量减少、细胞质减少、腺泡腔扩张，伴有被类似中央腺泡细胞内衬的管状结构取代的受影响腺泡。感染后3个月，观察到有产生黏液或不产生黏液上皮的小导管腺瘤样生长，这些变化可独立出现或同时出现。感染后4个月即出现胰腺癌。肿瘤病灶的数量和大小随时间增加，6个月后几乎所有感染的珍珠鸡都出现了肿瘤病灶。个别病例的癌灶中发现了A 型和D型内分泌细胞的肿瘤性增殖。其他相关肿瘤为骨肿瘤和十二指肠黏膜乳头状瘤样生长。
