Ramesh Manish, Karagic Merhunisa
a Montefiore Medical Center , Bronx, NY , USA.
Hum Vaccin Immunother. 2018;14(12):2848-2863. doi: 10.1080/21645515.2018.1502126. Epub 2018 Sep 14.
Allergen immunotherapy is a rapidly evolving field. Although subcutaneous immunotherapy has been practiced for over a hundred years, improved understanding of the underlying immunological mechanisms has led to the development of new, efficacious and better tolerated allergen-derivatives, adjuvants and encapsulated allergens. Diverse routes of allergen immunotherapy - oral, sublingual, epicutanoeus and intralymphatic - are enabling immunotherapy for anaphylactic food allergies and pollen-food allergy syndrome, while improving the tolerability and effectiveness of aeroallergen immunotherapy. The addition of Anti-IgE therapy decreases adverse effects of subcutaneous and oral immunotherapy.
变应原免疫疗法是一个快速发展的领域。尽管皮下免疫疗法已应用了一百多年，但对潜在免疫机制的深入了解促使了新型、有效且耐受性更好的变应原衍生物、佐剂和包封变应原的开发。变应原免疫疗法的多种途径——口服、舌下、皮内和淋巴内——正在使过敏性食物过敏和花粉 - 食物过敏综合征的免疫疗法成为可能，同时提高了气传变应原免疫疗法的耐受性和有效性。添加抗IgE疗法可降低皮下和口服免疫疗法的不良反应。
